Pain and Movement Responses to Resistance Training to Muscular Failure in Patients With Patellofemoral Pain

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07812519

Enrollment

Registered

2026-09-10

Start date

2026-12-01

Completion date

2028-05-01

Last updated

2026-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patellofemoral Pain Syndrome

Keywords

Patellofemoral Pain, Biomechanichs, Single leg squat

Brief summary

This study aims to investigate the effect of training to muscular failure in patients with patellofemoral pain (PFP). In a cross-sectional observational design, participants with PFP will be be performing a knee exercise to voluntarily muscular failure. The participants will throughout the exercise trial report pain levels and continue until 1) not being able to perform the exercise as instructed or 2) reaching a pain level of 5/10 (which is a common threshold for acceptable pain within rehabilitation). During this trial, the participants will be filmed and a biomechanical analysis will be performed to see if/how compensatory movements occur.

Interventions

OTHEREXERCISE TRAINING WITH OR WITHOUT MEDICATION

Resistance training to muscular failure in patients with patellofemoral pain.

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

15 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients diagnosed with PFP in only one knee by a licensed healthcare professional. * Aged 15-35 years. * A physical activity level of 3/10 or higher on the Tegner Activity Scale before the injury.

Exclusion criteria

* Any prior injury or condition with residual symptoms that may affect the results. * Current injury or condition affecting the performance of the test. * Resting pain greater than 0-1/10 on the Numeric Pain Rating Scale (NRS) and pain greater than 1-2/10 during light daily activities such as walking, sitting, standing, or climbing stairs.

Design outcomes

Primary

Measure	Time frame	Description
Pain Response	Approximately 24 hours, from baseline before the trial and the day after the trial.	Numeric pain rating scale 0-10. Participants will rate their perceived pain at baseline before the trial, during the trial and the day after the trial.
Knee extensor moment (Nm)	Changes in knee extensor moment between the first and final repetition during the trial, approximately 2 minutes.	Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)
Hip extensor moment (Nm)	Changes in hip extensor moment between the first and final repetition during the trial, approximately 2 minutes.	Will be measured using force plates and a 3d camera biomechanic analysis system (qualisys)
Knee flexion angle (degrees)	Changes between in knee flexion angle between the first and final repetition during the trial, approximately 2 minutes.	Knee flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)
Hip flexion angle (degress)	Changes between in hip flexion angle between the first and final repetition during the trial, approximately 2 minutes.	Hip flexion angle will be measured using a 3d camera biomechanical analysis system (qualisys)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 11, 2026