Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects

Implant Survival After Reconstructive Surgical Therapy of Peri-implantitis-related Bone Defects With Different Defect Configurations

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07809334

Acronym

Bony defects

Enrollment

Registered

2026-09-09

Start date

2026-09-01

Completion date

2027-06-30

Last updated

2026-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implantitis

Keywords

Peri-implantitis, Surgical treatment

Brief summary

To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).

Detailed description

The original population of this case series consisted of 75 patients with one crater-like defect and probing depth (PD) ≥6 mm. After flap elevation, defects were assigned to one characteristic class and treated by means of DBBMC. Following healing, patients were enrolled in an individualized supportive periodontal/ peri-implant (SPT) program.

Interventions

PROCEDUREReconstructive therapy

Intervention: Following the elevation of a muco-periosteal flap, all granulation tissue was completely removed from the defect area, by means of titanium curettes and a titanium brush under irrigation. Consequently, implant surfaces were covered with EDTA 24% for 2 min and chlorhexidine 1% gel for 2 min. Thereafter, the infrabony defects were filled with a deproteinized bovine bone mineral with 10% collagen. All patients were asked to follow an individualized supportive care program.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients rehabilitated with oral dental implants affected by peri-implantitis * A single peri-implantitis crater-like lesion with a Probing depth ofof ≥6 mm * No implant mobility, * Smokers

Exclusion criteria

* Probing depth \<6 mm; * Class II defects (characterized by consistent horizontal bone loss); * Multiple defects; * Implant mobility; * Subjects not interested in participating in the study;

Design outcomes

Primary

Measure	Time frame	Description
Implant survival rate	From enrollment to the end of treatment at the 10-year follow-up visit	Clinical Examination: Number of implants treated for peri-implantitis present in the oral cavity at the latest follow-up over the overall number of implants treated, expressed in %

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 10, 2026