Chest X-Ray Versus Lung Ultrasound in Neonatal Pneumonia

Chest X-Ray Versus Chest Ultrasound in Diagnosis of Neonatal Pneumonia

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07807514

Enrollment

100

Registered

2026-09-08

Start date

2026-09-02

Completion date

2028-07-20

Last updated

2026-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal Pneumonia, Pneumonia Neonatal, Respiratory Distress Syndrome

Keywords

Point-of-care ultrasound, Diagnostic accuracy, Chest X-ray, Lung ultrasound, Neonatal pneumonia

Brief summary

This prospective observational study aims to compare the diagnostic accuracy of chest X-ray versus lung ultrasound in the diagnosis of neonatal pneumonia among neonates admitted to the Neonatal Intensive Care Unit of Assiut University Children's Hospital.

Detailed description

Neonatal pneumonia is a leading cause of respiratory morbidity and mortality in the neonatal period. Chest X-ray has traditionally been the reference imaging modality, but it involves ionizing radiation and has moderate sensitivity. Lung ultrasound is a radiation-free, bedside alternative that has shown promising diagnostic performance. This prospective study will include term and preterm neonates admitted to the NICU with clinical suspicion of pneumonia within the first 28 days of life. All participants will undergo both portable chest X-ray and standardized lung ultrasound performed by trained examiners blinded to each other's findings. Diagnostic accuracy of both modalities will be compared against a composite clinical reference standard.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 28 Days

Healthy volunteers

Inclusion criteria

* \- Neonates (term and preterm) admitted to the NICU * Clinical diagnosis of pneumonia within the first 28 days of life * Written informed consent from parents or legal guardians

Exclusion criteria

* \- Major congenital pulmonary or cardiac structural malformations that would confound imaging interpretation * Lethal congenital anomalies or chromosomal abnormalities incompatible with survival

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic accuracy of lung ultrasound versus chest X-ray	At the time of clinical suspicion of pneumonia (Baseline)	Sensitivity, specificity, positive predictive value, and negative predictive value of lung ultrasound compared with chest X-ray for the diagnosis of neonatal pneumonia, using a composite clinical reference standard.

Secondary

Measure	Time frame	Description
Comparison of radiographic and sonographic findings	Baseline	Description and comparison of chest X-ray findings (opacities, air bronchograms, pleural effusion) and lung ultrasound findings (subpleural consolidation, dynamic air bronchograms, B-lines, pleural line abnormalities).
Correlation with clinical severity	Baseline	Correlation between chest X-ray grading and lung ultrasound scores with clinical severity indices of neonatal respiratory distress (oxygenation index, FiO2 requirement, respiratory support level).
Risk factors associated with neonatal pneumonia	Baseline	Antenatal, perinatal, and postnatal risk factors associated with the diagnosis of neonatal pneumonia.

Contacts

CONTACTRana H Rayan, Resident

Rana.18313199@med.aun.edu.eg+20 10 69579624

STUDY_CHAIRKhaled A Sanousy, prof

Pediatrics Department, Assiut University Hospitals

Outcome results