Heart Arrest
Conditions
Keywords
naloxone, in-hospital cardiac arrest
Brief summary
The goal of this clinical trial is to learn if the drug naloxone in addition to cardiopulmonary resuscitation improves outcomes of in-hospital cardiac arrets. The main questions it aims to answer are: Does naloxone improve survival after the cardiac arrest? Does naloxone improve functional outcome in survivors of cardiac arrest? Does naloxone improve health related quality of life after the cardiac arrest? How common are adverse reactions to naloxone when administered during cardiopulmonary resuscitation. Researchers will compare naloxone to a placebo (a look-alike substance that contains no drug) to see if naloxone works during cardiac arrest.
Interventions
DRUGnaloxone
2 mg naloxone administered intravenously or intraosseously
DRUGPlacebo
0.9% saline administered intravenously or intraosseously
Sponsors
Region Skane
Lund University
Clinical Studies Sweden - Forum South
Copenhagen Trial Unit, Center for Clinical Intervention Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. In-Hospital Cardiac Arrest 2. Age ≥ 18 years 3. Received at least one dose of adrenaline during CPR
Exclusion criteria
1. "Do-not-resuscitate"-order 2. Known/suspected pregnancy 3. Known objection by the patient to participate in the trial 4. Previous inclusion in the trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 30-day survival | 30 days after the cardiac arrest | proportion of patients alive |
Contacts
CONTACTAnna Lybeck, MD PhD
Outcome results
None listed