Dexmedetomidine for Sedation in Patients Requiring Mechanical Ventilation is Associated With a Lower Incidence of Delirium

Dexmedetomidine for Sedation in Patients Requiring Mechanical Ventilation is Associated With a Lower Incidence of Delirium : A Retrospective Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07806188

Enrollment

412

Registered

2026-09-08

Start date

2026-08-20

Completion date

2027-01-20

Last updated

2026-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation

Brief summary

This retrospective cohort study will include 412 adults mechanically ventilated \>24 hours in intensive care unit in sohag university hospital between 2024 and 2026). Participants will be assigned to either, EGDS group ( equal to 208 ) or conventional sedation group (equal to 204 ). The main endpoint will be measured is the incidence of delirium in ICU , measured by the Confusion Assessment Method for the ICU (CAM-ICU). Secondary endpoints will be the number of the days free from ventilation at 28 days (VFDs), ICU length of stay (LOS) in the ICU, and the death during hospitalization.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Consecutive adult patients aged 18 years or older who required invasive mechanical ventilation for more than 24 hours.

Exclusion criteria

* Neurological primary admission such as stroke or traumatic brain injury. * Active seizures or alcohol withdrawal at admission. * Prior dementia or severe cognitive impairment. * Mechanical ventilation \<24 hours. * Death within 48 hours of admission. * Missing essential sedation or delirium data.

Design outcomes

Primary

Measure	Time frame	Description
occurrence of delirium during the ICU admission	Within 12 hours of intubation	main end point: occurrence of delirium during the ICU admission , defined as at least one positive CAM-ICU assessment.

Secondary

Measure	Time frame
Number of Ventilator-free days (VFDs)	6 months
duration of ICU stay (LOS)	6 months

Outcome results