Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.

Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection. A Prospective Randomised Controlled Trial)

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07806162

Enrollment

120

Registered

2026-09-08

Start date

2026-09-01

Completion date

2026-11-01

Last updated

2026-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PONV

Brief summary

The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.

Interventions

DRUGOpioid Free Anaesthesia

The OFA group protocol consists of a combination of intravenous lidocaine, ketamine, dexmedetomidine, and propofol TIVA.

DRUGconventential opioid-based anaesthesia (OBA,

The OBA group protocol consists of balanced anaesthesia with fentanyl plus sevoflurane.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

- * Eligible participants were adults (18-80 years). * Prepared for elective thoracoscopic lobectomy or segmentectomy for lung cancer under general anaesthesia

Exclusion criteria

* Contraindication to any study drug (e.g., heart block, severe liver disease, allergy). * Chronic opioid use (\>30 MME/day for \>3 months). * Patients with renal impairment (e GFR \<30 mL/min). * Pregnancy. * Inability to comprehend pain scales.

Design outcomes

Primary

Measure	Time frame
the occurrence of PONV during the initial 24 hours	24 hours

Secondary

Measure	Time frame
total opioid consumption over 24 hour (expressed as morphine milligram equivalents.	24 hours
pain intensity scores (numerical rating scale NRS 0-10)	24 hours
recovery quality (QoR-15 score)	24 hours

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 9, 2026