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Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women

Investigation of the Effects of Different Types of Exercise on Irisin, Leptin, and Ghrelin Levels in Sedentary Women

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07805772
Acronym
ILEX
Enrollment
20
Registered
2026-09-04
Start date
2026-09-05
Completion date
2026-09-30
Last updated
2026-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Physiology, Metabolic Hormones

Keywords

Irisin, Leptin, Ghrelin, Sedentary Women

Brief summary

This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study. Hormonal responses will be evaluated in relation to the exercise sessions to determine exercise-induced changes in irisin, leptin, and ghrelin and to compare the responses associated with the three exercise modalities.

Detailed description

This interventional study is designed to investigate and compare the acute effects of aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT) on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study. Participants will complete three different exercise conditions: aerobic exercise, anaerobic exercise, and HIIT. Irisin, leptin, and ghrelin levels will be evaluated in relation to each exercise condition to determine acute exercise-induced hormonal responses. The study will compare changes in these biomarkers across the three exercise modalities to determine whether the hormonal responses differ according to exercise type. The study is intended to provide a better understanding of the acute endocrine and metabolic responses to exercise modalities with different physiological demands in sedentary women, with particular emphasis on irisin, leptin, and ghrelin.

Interventions

BEHAVIORALAerobic Exercise

Participants will complete an aerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to aerobic exercise.

Participants will complete an anaerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to anaerobic exercise.

BEHAVIORALHigh-Intensity Interval Training (HIIT)

Participants will complete a high-intensity interval training (HIIT) session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to HIIT.

Sponsors

Inonu University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE

Masking description

No masking was applied because participants and investigators were aware of the exercise condition performed during each session.

Intervention model description

All participants will complete three exercise conditions-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-in separate sessions. Each participant will therefore serve as her own control, allowing within-participant comparisons of irisin, leptin, and ghrelin responses across the three exercise modalities.

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 24 Years
Healthy volunteers
Yes

Inclusion criteria

Female participants Sedentary individuals Voluntary participation in the study Ability and willingness to complete the planned exercise sessions

Exclusion criteria

Inability to participate in the planned exercise sessions Withdrawal of consent or unwillingness to continue participation

Design outcomes

Primary

MeasureTime frameDescription
Change in Irisin LevelPre-exercise and immediately post-exercise during each exercise sessionIrisin levels will be assessed in relation to each exercise condition to determine the change in circulating irisin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)
Change in Leptin LevelPre-exercise and immediately post-exercise during each exercise sessionLeptin levels will be assessed in relation to each exercise condition to determine the change in circulating leptin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).
Change in Ghrelin LevelPre-exercise and immediately post-exercise during each exercise sessionGhrelin levels will be assessed in relation to each exercise condition to determine the change in circulating ghrelin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).

Countries

Turkey (Türkiye)

Contacts

CONTACTÖzgür EKEN, PhD
ozgur.eken@inonu.edu.tr+905532132795

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 5, 2026