Dandruff, Itchy Scalp, Pruritus
Conditions
Brief summary
This is a single-center, cross-sectional, observational clinical study to investigate the clinical attributes and lipidomic signatures of itchy scalp with and without dandruff, aiming to validate the biological distinctiveness of pure scalp pruritus. A total of 132 female participants were enrolled and allocated to three cohorts (44 participants each) based on scalp pruritus and dandruff status. Clinical scoring, instrumental biophysical measurements, self-assessment questionnaires, and lipidomic signatures were analyzed and compared across groups.
Interventions
None listed
Sponsors
L'Oreal
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Female volunteer from 18 to 50 years old, in good general health (physical, mental, and social well-being) according to volunteer self-declaration and investigator's opinion. 2. Female of childbearing potential who is not sexually active, or who is using an effective contraceptive method for at least one month before the beginning of the study and throughout the study. 3. Female of childbearing potential willing to undergo urine pregnancy test. 4. Volunteer has the life habit of washing hair twice to 7 times every week. 5. Volunteer has scalp conditions based on group: a. Group 1 i. Self-declared normal scalp without pruritus, score=0 on pruritus Visual Analog Scale (VAS). ii. Adherent dandruff score ≤0.5 based on Dandruff Photographic Scales (DFS) assessed by dermatologist. b. Group 2 i. Scalp pruritus score ≥4 and ≤8 on pruritus VAS. ii. Adherent dandruff score ≥2 and ≤4 based on DFS assessed by dermatologist. c. Group 3 i. Scalp pruritus score ≥4 and ≤8 on pruritus VAS. ii. Adherent dandruff score ≤0.5 based on DFS assessed by dermatologist. 6. Volunteer with Asian scalp. 7. Volunteer living in Shanghai for at least one year. 8. Volunteer willing and able to fulfil the study requirements and schedule. 9. Volunteer informed about the study objectives and procedures, and able to understand them. 10. Volunteer who has given written informed consent.
Exclusion criteria
1. Volunteer who is pregnant or lactating or who is planning to become pregnant during the study. 2. Menopausal female (with absence of menstruations for less than one year) or post-menopausal female (with absence of menstruations for more than one year). 3. Volunteer who has hair treatments including hair coloration, bleaching or perm within 3 months before inclusion. 4. Volunteer who has skin cancer, severe autoimmune skin diseases or other moderate or severe skin diseases. 5. Volunteer who has Seborrheic dermatitis, psoriasis, scalp pityriasis, tinea capitis, atopic dermatitis, folliculitis, alopecia or other skin disorders might interfere the assessment on scalp or calves determined by the dermatologist. 6. Volunteer who has diagnosed endocrine disorders (e.g. hypopituitarism, diabetes mellitus, polycystic ovary syndrome), auto-immune medical conditions (e.g. systemic lupus erythematosus (SLE) and Rheumatoid arthritis (RA)), hyper- or hypothyroidism, hypertension or mental illness (e.g. diagnosed depression, schizophrenia, trichotillomania). 7. Volunteer who has active gastrointestinal (GI) bleeding or history of heart or vascular disease. 8. Volunteer who has systemic medication (e.g. steroidal and non-steroidal anti-inflammatory drugs, corticoids, insulin, antihistamines, hormones, antihypertensive, antibiotics such as quinolone, tetracycline, thiazides, fluoroquinolones) within one month before inclusion. 9. Volunteer who has topical treatments of prescription, over-the-counter remedies (e.g. minoxidil, ketoconazole, selenium sulfide lotion) on scalp within 2 months before inclusion. 10. Volunteer who changed her routine shampoo within 2 weeks before inclusion. 11. Volunteer who has conditions considered by the Investigator as sound reasons for disqualification from enrolment into the study, because it might put the individual at significant risk, confound study results or interfere with the individual's participation. 12. Volunteer who declares to be deprived of freedom by administrative or legal decision. 13. Volunteer who cannot be contacted by phone in case of emergency. 14. Volunteer having participated within 30 days before inclusion or currently participating in another clinical study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| High-coverage targeted lipidomics | Day 1 (Single assessment at baseline) | Targeted lipidomics using membrane filter samples on scalp |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical scalp scoring | Day 1 (Single assessment at baseline) | Dermatologist-assessed erythema (0: none to 5: severe), greasiness (0: none to 3: severe), dryness (0: none to 9: severe), and clinical scalp type classification (dry, normal, greasy, or mixed). |
| Transepidermal Water Loss (TEWL) | Day 1 (Single assessment at baseline) | Evaluated on scalp sites using Tewameter® TM Nano (Courage + Khazaka electronic GmbH), expressed in g/h/m². |
| Scalp hydration | Day 1 (Single assessment at baseline) | Stratum corneum hydration level measured using DermaLab Hydration Pin Probe (Cortex Technology), expressed in arbitrary units (AU). |
| Scalp sebum level | Day 1 (Single assessment at baseline) | Sebum excretion level measured using Sebumeter® SM815 (Courage + Khazaka electronic GmbH), expressed in µg/cm². |
| Scalp surface pH | Day 1 (Single assessment at baseline) | Measured using Skin-pH-Meter PH905 (Courage + Khazaka electronic GmbH). |
Countries
China
Outcome results
None listed