NLR and PLR in H. Pylori-Associated Gastritis

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Helicobacter Pylori-Associated Gastritis

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07805005

Enrollment

Registered

2026-09-04

Start date

2026-09-01

Completion date

2028-05-01

Last updated

2026-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspepsia, Gastritis, Helicobacter Pylori Infection

Keywords

Helicobacter pylori, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Gastritis, Inflammatory markers

Brief summary

This cross-sectional study aims to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with Helicobacter pylori-associated gastritis at Assiut University Hospitals.

Detailed description

Helicobacter pylori is a major cause of gastritis and is associated with chronic gastric inflammation. Systemic inflammatory markers derived from complete blood count, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been proposed as simple and inexpensive indicators of inflammation. This cross-sectional study will include adult patients with dyspepsia undergoing testing for H. pylori by endoscopy and biopsy at Assiut University Hospitals. Complete blood count will be performed to calculate NLR and PLR. The study will assess the association of these ratios with the presence of H. pylori infection and the severity of gastritis.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* \- Age 18 years or older * Patients with dyspepsia * Patients undergoing endoscopy and biopsy for H. pylori testing * Willingness to provide informed consent

Exclusion criteria

* \- Hematological diseases * Active infection other than H. pylori * Chronic inflammatory or autoimmune diseases * Malignancy * Recent use of steroids or immunosuppressive drugs * Recent acute bleeding

Design outcomes

Primary

Measure	Time frame	Description
Neutrophil-to-lymphocyte ratio (NLR) in H. pylori-associated gastritis	Baseline	Neutrophil-to-lymphocyte ratio calculated from complete blood count in patients with confirmed H. pylori-associated gastritis compared with patients without H. pylori infection.

Secondary

Measure	Time frame	Description
Diagnostic performance of PLR	Baseline	Sensitivity, specificity, and optimal cutoff value of PLR for predicting H. pylori infection using ROC curve analysis.
Correlation of NLR and PLR with severity of gastritis	Baseline	Correlation coefficient between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values and the severity grade of gastritis based on endoscopic and/or histopathological findings, using Spearman or Pearson correlation as appropriate.
Platelet-to-lymphocyte ratio (PLR)	Baseline	Platelet-to-lymphocyte ratio calculated from complete blood count in patients with and without H. pylori infection.
Diagnostic performance of NLR	Baseline	Sensitivity, specificity, and optimal cutoff value of NLR for predicting H. pylori infection using receiver operating characteristic (ROC) curve analysis.

Contacts

CONTACTHadeer A Mohamed, Resident

Hadeer.18313571@med.aun.edu.eg+20 11 25445957

STUDY_CHAIRRania m Hafez, prof

Internal Medicine Department, Assiut University Hospitals

Outcome results