Primary Sjögren Syndrome, Sarcopenia
Conditions
Keywords
primary sjogren syndrome, Sarcopenia, muscle mass, hand grip strength, physical performance, functional status
Brief summary
The aim of this study is to evaluate the frequency of probable sarcopenia and sarcopenia in patients with primary Sjögren syndrome and to investigate the effects of sarcopenia on functional status, muscle strength, and quality of life. Adult patients diagnosed with primary Sjögren syndrome will be included in the study. Muscle strength, muscle mass, physical performance, and functional status will be assessed using various evaluation methods
Detailed description
Primary Sjögren syndrome is a chronic autoimmune inflammatory disease that may affect the musculoskeletal system. Sarcopenia is characterized by decreased muscle mass and muscle strength and may lead to impaired physical performance and functional capacity. In this cross-sectional study, the presence of probable sarcopenia and sarcopenia in adult patients with primary Sjögren syndrome will be evaluated. Demographic characteristics, disease duration, and clinical findings of the participants will be recorded. Muscle strength will be assessed using handgrip strength testing, and physical performance will be evaluated using functional performance tests. In addition functional status scales will be administered. The study aims to determine the effects of sarcopenia on functional status and quality of life in patients with primary Sjögren syndrome.
Interventions
DIAGNOSTIC_TESTdexa, hand grip strength, myostatin, follistatin
Although these parameters are frequently assessed in other rheumatological diseases, few studies have previously examined such a wide range of parameters in patients with primary Sjögren's syndrome.
Sponsors
Antalya Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Voluntarily 2. Women over the age of 18 3. Women diagnosed with primary Sjögren's syndrome
Exclusion criteria
1. Those with cognitive impairment 2. Pregnancy 3. Malignancy 4. Those with other rheumatic diseases 5. Uncontrolled chronic disease(diabetes mellitus, hypertension, hypothyroidism, hyperthyroidism) 6. Those who have difficulty walking on their own 7. Arthritis present in the dominant hand joints 8. Central and peripheral nervous system findings 9. Myositis and mechanical pain 10. Individuals receiving treatment for hyperlipidemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| muscle strength | 12 month | Muscle strength will be assessed using hand-held dynamometry. Measurements will be recorded in kilograms-force (kgf) and compared between primary Sjögren syndrome patients and healthy controls. |
| muscle mass | 12 months | Muscle mass will be assessed using DEXA. Results will be compared between groups. |
| functional status | 12 months | Functional status will be evaluated using validated functional assessment scales. Scores will be compared between primary Sjögren syndrome patients and healthy controls. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| myostatin | 12 months | Serum myostatin levels will be measured using enzyme-linked immunosorbent assay (ELISA) and compared between groups. |
| follistatin | 12 months | Serum follistatin levels will be measured using enzyme-linked immunosorbent assay (ELISA) and compared between groups. |
Countries
Turkey (Türkiye)
Contacts
STUDY_DIRECTORMehmet Çetin, research asistant
Antalya Training and Research Hospital
Outcome results
None listed