Echocardiography, Healthy, Healthy Adult, Hemodynamic Changes, High Altitude, High Altitude Effects, Pulmonary Resistance
Conditions
Keywords
Hypoxia, High Altitude, Pulmonary resistance, Health, Echocardiography, Hemodynamics
Brief summary
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently \>2600m.
Detailed description
The aim of this research is to investigate the pulmonary resistance (sPAP/CO) by echocardiography and other hemodynamic outcomes before and after re-ascent (sea level for 7 days vs. re-ascent to 2850m) in healthy individuals, who permanently live at high altitude over 2600m
Interventions
BEHAVIORALRe-Ascent from sea level to 2850m
After 7 days at sea level return/re-ascent to their usual living altitude at 2850m
Sponsors
Silvia Ulrich Somaini
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Healthy individuals living permanently \> 2600m around Quito (Ecuador) will be assessed after 7 days at sea level and after re-ascent to 2850m
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18-80 years and of all genders * Permanent residence \> 2600 m. * healthy: no self-perceived cardiopulmonary disease limiting daily activities * written informed consent to participate in the study.
Exclusion criteria
* Age \<18 years or \>80 years * Participants who cannot follow the study investigations * Participants permanently living \< 2600m. * Participants who traveled and stayed overnight at altitudes \<2000 m in the past 4 weeks. * any self-perceived cardiopulmonary disease limiting daily activities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary resistance (sPAP/CO) after re-ascent to 2850m | From Day 5-7 at sea level to the day after re-ascent | Difference in sPAP/CO by echocardiography between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PaO2 after re-ascent to 2850m | From Day 7 at sea level to day after re-ascent (time frame of 3 days) | Difference/change in PaO2 (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals |
| PaCO2 after re-ascent to 2850m | From Day 7 at sea level to day after re-ascent (time frame of 3 days) | Difference/change in PaCO2 (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals |
| Hemoglobin after re-ascent to 2850m | From Day 7 at sea level to day after re-ascent (time frame of 3 days) | Difference/change in hemoglobin (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals |
| pH after re-ascent to 2850m | From Day 7 at sea level to day after re-ascent (time frame of 3 days) | Difference/change in pH (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals |
| Tricuspid regurgitation velocity TRV after re-ascent to 2850m | From Day 5-7 at sea level to the day after re-ascent | Difference/change in tricuspid regurgitation velocity TRV between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals |
| Cardiac output CO after re-ascent to 2850m | From Day 5-7 at sea level to the day after re-ascent | Difference/change in cardiac output CO between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals |
| Tricuspid annular plan systolic excursion TAPSE after re-ascent to 2850m | From Day 5-7 at sea level to day after re-ascent | Difference/change in tricuspid annular plan systolic excursion TAPSE between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals |
| Right ventricular strain after re-ascent to 2850m | From Day 5-7 at sea level to day after re-ascent | Difference/change in right ventricular strain between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals |
| Right atrial pressure RAP after re-ascent to 2850m | From Day 5-7 at sea level to day after re-ascent | Difference/change in rightatrial pressure RAP between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals |
| Pulmonary resistance (sPAP/CO) pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in pulmonary resistance (sPAP/CO) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Tricuspid regurgitation velocity TRV pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in tricuspid regurgitation velocity TRV at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Cardiac output CO pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in cardiac output CO at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Tricuspid annular plan systolic excursion TAPSE pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in tricuspid annular plan systolic excursion TAPSE at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Right ventricular strain pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in right ventricular strain at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Right atrial pressure RAP pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in right atrial pressure at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Fractional area change FAC pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in fractional area change FAC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| PaO2 pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in PaO2 (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| PaCO2 pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in PaCO2 (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Hemoglobin pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in hemoglobin (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Fractional area change FAC after re-ascent to 2850m | From Day 5-7 at sea level to day after re-ascent | Difference/change in fractional area change FAC between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals |
| pH pre-descent to after re-ascent | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in pH (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
Countries
Switzerland
Contacts
CONTACTSilvia Ulrich, Prof. Dr. med.
CONTACTMichael Furian, Prof. Dr. sc. ETH
PRINCIPAL_INVESTIGATORSilvia Ulrich
University Hospital Zurich, Departement of Pulmonology
PRINCIPAL_INVESTIGATORRodrigo Hoyos
Hospital Carlos Andrade Marin of Quito, Ecuador
Outcome results
None listed