Healthy, Healthy Adult, High Altitude, High Altitude Effects, Lung Function Changes, Lung Function Tests
Conditions
Keywords
Health, High altitude, Lung function, Forced oscillation technique
Brief summary
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live permanently \> 2600m.
Detailed description
The aim of this research is to investigate the lung function and pulmonary resistance/reactance before and after re-ascent (sea level for 7 days after prior descent from 2850m vs. re-ascent to 2850m) in healthy individuals, who permanently live at high altitude over 2600m.
Interventions
BEHAVIORALRe-ascent from sea level to 2850m
Descent from 2850m to sea level with a stay for 7 days and re-ascent/return back to their usual living altitude at 2850m
Sponsors
Silvia Ulrich Somaini
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Healthy participants living permanently \> 2600m around Quito (Ecuador) will be assessed at 2850m, after relocation to sea level for 7 days and after re-ascent
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18-80 years and of all genders * Permanent residence \> 2600 m * healthy: no self perceived cardiopulmonary disease limiting daily activities * written informed consent to participate in the study.
Exclusion criteria
* Age \<18 years or \>80 years * Participants who cannot follow the study investigations * Participants permanently living \< 2600m * Participants who traveled and stayed overnight at altitudes \<2000 m in the past 4 weeks. * any self-perceived cardiopulmonary disease limiting daily activities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FEV1 after re-ascent to 2850m | From Day 4 at sea level to the day after re-ascent (Day 9) | Difference/change in forced expiratory volume in one second FEV1 between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Forced Vital Capacity FVC after re-ascent to 2850m | From Day 4 at sea level to the day after re-ascent (Day 9) | Difference/change in forced vital capacity FVC between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals |
| FEV1/FVC after re-ascent to 2850m | From Day 4 at sea level to the day after re-ascent (Day 9) | Difference/change in FEV1/FVC between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals |
| Respiratory Impedance (forced oscillation technique) after re-ascent to 2850m | From Day 4 at sea level to the day after re-ascent (Day 9) | Difference/change in respiratory impedance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals |
| Respiratory resistance (forced oscillation technique) after re-ascent to 2850m | From Day 4 at sea level to the day after re-ascent (Day 9) | Difference/change in respiratory resistance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals |
| Respiratory reactance (forced oscillation technique) after re-ascent to 2850m | From Day 4 at sea level to the day after re-ascent (Day 9) | Difference/change in respiratory reactance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals |
| FEV1 after 4 days at sea level | From high altitude (2850m) to day 4 at sea level | Difference/change in FEV1 between 2850m (prior to descent) and day 4 at sea level in healthy individuals |
| Forced Vital Capacity FVC after 4 days at sea level | From high altitude (2850m) to day 4 at sea level | Difference/change in forced vital capacity FVC between 2850m (prior to descent) and day 4 at sea level in healthy individuals |
| FEV1/FVC after 4 days at sea level | From high altitude (2850m) to day 4 at sea level | Difference/change in FEV1/FVC between 2850m (prior to descent) and day 4 at sea level in healthy individuals |
| Respiratory Impedance (forced oscillation technique) after 4 days at sea level | From high altitude (2850m) to day 4 at sea level | Difference/change in respiratory Impedance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in healthy individuals |
| Respiratory resistance (forced oscillation technique) after 4 days at sea level | From high altitude (2850m) to day 4 at sea level | Difference/change in respiratory resistance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in healthy individuals |
| Respiratory reactance (forced oscillation technique) after 4 days at sea level | From high altitude (2850m) to day 4 at sea level | Difference/change in respiratory reactance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in healthy individuals |
| FEV1 pre-descent and after re-ascent (2850m) | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in FEV1 at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Forced Vital Capacity FVC pre-descent and after re-ascent (2850m) | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in forced vital capacity FVC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| FEV1/FVC pre-descent and after re-ascent (2850m) | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in FEV1/FVC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Respiratory Impedance (forced oscillation technique) pre-descent and after re-ascent (2850m) | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in respiratory impedance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Respiratory resistance (forced oscillation technique) pre-descent and after re-ascent (2850m) | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in respiratory resistance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
| Respiratory reactance (forced oscillation technique) pre-descent and after re-ascent (2850m) | Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days) | Difference/change in respiratory reactance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals |
Countries
Switzerland
Contacts
CONTACTSilvia Ulrich, Prof. Dr. med.
CONTACTMichael Furian, Prof. Dr. sc. ETH
PRINCIPAL_INVESTIGATORSilvia Ulrich
University Hospital Zurich, Departement of Pulmonology
PRINCIPAL_INVESTIGATORRodrigo Hoyos
Hospital Carlos Andrade Marin of Quito, Ecuador
Outcome results
None listed