Echocardiography, Healthy, Healthy Adult, Hemodynamic Changes, High Altitude, Pulmonary Resistance
Conditions
Keywords
Hypoxia, High altitude, Health, Echocardiography, Pulmonary resistance, Hemodynamics
Brief summary
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently \>2600m.
Detailed description
The aim of this research is to investigate the pulmonary resistance (sPAP/CO) by echocardiography and other hemodynamic outcomes before and after relocation (high altitude near their living altitude vs. sea level) in healthy individuals, who permanently live at high altitude over 2600m.
Interventions
BEHAVIORALDescent from 2850m to sea level
Descent from 2850m to sea level with a stay for 7 days
Sponsors
Silvia Ulrich Somaini
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Healthy individuals living permanently \> 2600m around Quito (Ecuador) will be assessed at 2850m and after relocation to sea level
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18-80 years and of all genders * Permanent residence \> 2600 m * healthy: no self-perceived cardiopulmonary disease limiting daily activities * written informed consent to participate in the study.
Exclusion criteria
* Age \<18 years or \>80 years * People who cannot follow the study investigations * Participant permanently living \< 2600m. * Participant who traveled and stayed overnight at altitudes \<2000 m in the past 4 weeks. * any self-perceived cardiopulmonary disease limiting daily activities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary resistance (sPAP/CO) after 7 days at sea level | From high altitude (2850m) to day 5-7 at sea level | Difference/change in sPAP/CO by echocardiography between 2850m and Day 5-7 at sea level in healthy individuals |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tricuspid regurgitation velocity TRV after 7 days at sea level | From high altitude (2850m) to day 5-7 at sea level | Difference/change in tricuspid regurgitation velocity TRV between 2850m and Day 5-7 at sea level in healthy individuals |
| Cardiac output CO after 7 days at sea level | From high altitude (2850) to day 5-7 at sea level | Difference/change in cardiac output CO between 2850m and Day 5-7 at sea level in healthy individuals |
| Tricuspid annular plan systolic excursion TAPSE after 7 days at sea level | From high altitude (2850m) to day 5-7 at sea level | Difference/change in tricuspid annular plan systolic excursion TAPSE between 2850m and Day 5-7 at sea level in healthy individuals |
| Right ventricular strain after 7 days at sea level | From high altitude (2850m) to Day 5-7 at sea level | Difference/change in right ventricular strain between 2850m and day 5-7 at sea level in healthy individuals |
| Right atrial pressure RAP after 7 days at sea level | From high altitude (2850m) to Day 5-7 at sea level | Difference/change in right atrial pressure RAP between 2850m and day 5-7 at sea level in healthy individuals |
| Fractional area change FAC after 7 days at sea level | From high altitude (2850m) to Day 5-7 at sea level | Difference/change in fractional area change FAC between 2850m and day 5-7 at sea level in healthy individuals |
| PaO2 after 7 days at sea level | From high altitude (2850) to day 7 at sea level | Difference/change in PaO2 (arterial blood gas analysis) between 2850m and sea level in healthy individuals |
| PaCO2 after 7 days at sea level | From high altitude (2850) to day 7 at sea level | Difference/change in PaCO2 (arterial blood gas analysis) between 2850m and sea level in healthy individuals |
| Hemoglobin after 7 days at sea level | From high altitude (2850) to day 7 at sea level | Difference/change in hemoglobin (arterial blood gas analysis) between 2850m and sea level in healthy individuals |
| pH after 7 days at sea level | From high altitude (2850) to day 7 at sea level | Difference/change in pH (arterial blood gas analysis) between 2850m and sea level in healthy individuals |
| Acclimatization-Effect of pulmonary resistance (sPAP/CO) at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in pulmonary resistance (sPAP/CO) within a stay at sea level of 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of tricuspid regurgitation velocity TRV at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in tricuspid regurgitation velocity TRV within a stay at sea level of 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of cardiac output CO at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in cardiac output CO within a stay at sea level of 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of tricuspid annular plan systolic excursion TAPSE at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in tricuspid annular plan systolic excursion TAPSE within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of right ventricular strain at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in right ventricular strain within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of right atrial pressure RAP at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in right atrial pressure RAP within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of fractional area change FAC at sea level | From Day 2 to Day 5-7 at sea level | Difference/change in fractional area change FAC within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of PaO2 at sea level | From Day 2 to Day 7 at sea level | Difference/change in PaO2 (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of PaCO2 at sea level | From Day 2 to Day 7 at sea level | Difference/change in PaCO2 (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of hemoglobin at sea level | From Day 2 to Day 7 at sea level | Difference/change in hemoglobin (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
| Acclimatization-Effect of pH at sea level | From Day 2 to Day 7 at sea level | Difference/change in pH (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals |
Countries
Switzerland
Contacts
CONTACTSilvia Ulrich, Prof. Dr. med.
CONTACTMichael Furian, Prof. Dr. sc. ETH
PRINCIPAL_INVESTIGATORSilvia Ulrich
University Hospital Zurich, Departement of Pulmonology
PRINCIPAL_INVESTIGATORRodrigo Hoyos
Hospital Carlos Andrade Marin of Quito, Ecuador
Outcome results
None listed