Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis in the Knee, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
Conditions
Keywords
osteoarthritis, arthritis, corticosteroid, steroid injection, pain, pain control, pain survey, knee, knee arthritis, knee osteoarthritis, knee pain, knee injection
Brief summary
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Interventions
PROCEDUREAnteromedial Injection
If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.
PROCEDUREAnterolateral Injection
If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.
Sponsors
University of Chicago
AdventHealth
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
The population will be adults with symptomatic, radiographically moderate-to-severe medial compartment knee osteoarthritis who are already undergoing corticosteroid injections as part of routine care on their native knee. They wil be randomized to receive their injection on either the anteromedial or anterolateral knee.
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 40 * Clinical diagnosis of knee OA with predominant medial compartment symptoms * Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent) * Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee * Able to provide informed consent * Able to complete phone, email, or MyChart follow-ups in English
Exclusion criteria
* Predominant lateral compartment OA or patellofemoral-only OA * Inflammatory arthritis (RA, gout flare, etc.) * Suspected or confirmed joint infection or overlying cellulitis * Prior knee arthroplasty on the index knee * Planned surgery for index knee within 12-week follow-up * Inability to complete follow-up assessments * Other clinician-determined contraindication to CSI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numeric Pain Rating Scale | Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection | This survey asks patients to rate their pain on a scale from 0 to 10. |
| Knee Osteoarthritis and Outcome Score-Joint Replacement | Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection | This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Institutional Survey on Satisfaction with Injection | 2 weeks, 6 weeks, and 12 weeks post-injection | This survey asks patients to rate their satisfaction with their corticosteroid injection on a scale from 0 to 10. |
| Patient Global Impression of Change | 2 weeks, 6 weeks, and 12 weeks post-injection | This survey asks patients to rate their overall health status on a scale from 1 to 7. |
Countries
United States
Contacts
CONTACTMalik J Scott, B.A.
PRINCIPAL_INVESTIGATORSara JS Wallace, M.D./M.P.H.
The University of Chicago Medical Center
PRINCIPAL_INVESTIGATORBrandon Pardi, M.D.
AdventHealth
Outcome results
None listed