Prolonged Sitting, Sedentary Behavior, Vascular Health
Conditions
Brief summary
The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. The main questions it aims to answer are: Does interrupting prolonged sitting with short standing intervals (10 minutes every hour) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? Does interrupting prolonged sitting with prolonged intermittent standing intervals (30 minutes every hour divided into three 10-minute standing bouts) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? The researcher will compare three different sitting interruption conditions to evaluate their effects on vascular health outcomes: Standing for 10 minutes every hour. Continuous standing for 30 minutes every hour. Intermittent standing for 30 minutes every hour divided into three 10-minute standing bouts. Participants will: Attend three experimental sessions in random order separated by at least 7 days. Complete 3 hours of sitting with different standing interruption protocols. Undergo measurements of blood pressure, pulse wave velocity, and heart rate before sitting and after each hour of the experiment. Undergo height, weight, and body mass index measurements.
Interventions
BEHAVIORALShort Standing Interval
Participants will interrupt prolonged sitting with 10 minutes of standing every hour during 3 hours of sitting.
BEHAVIORALContinuous Standing Interval
Participants will interrupt prolonged sitting with 30 continuous minutes of standing every hour during 3 hours of sitting.
BEHAVIORALIntermittent Standing Interval
Participants will interrupt prolonged sitting with 30 minutes of standing every hour divided into three 10-minute standing bouts during 3 hours of sitting.
Sponsors
King Saud University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Participants will complete three experimental conditions in random order using a randomized crossover design. Each participant will undergo all three sitting interruption protocols with at least 7 days between sessions.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
Female participants aged 18-45 years. Healthy individuals with normal blood pressure levels (systolic blood pressure \<130 mmHg and diastolic blood pressure \<80 mmHg). Body mass index (BMI) less than 30 kg/m². Ability to stand without support. No history of cardiovascular disease or chronic diseases that may affect study outcomes.
Exclusion criteria
Pregnancy or breastfeeding. Back injuries preventing prolonged sitting. Use of medications that may affect cardiovascular responses, including antihypertensive, antidiabetic, antidepressant, or hormonal medications. Presence of chronic diseases or cardiovascular conditions affecting vascular health. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | Baseline, 1 hour, 2 hours, and 3 hours | Systolic and diastolic blood pressure will be measured before sitting and after each hour during the experimental sessions. |
| Pulse Wave Velocity | Baseline, 1 hour, 2 hours, and 3 hours | — |
| Heart Rate | Baseline, 1 hour, 2 hours, and 3 hours | — |
Countries
Saudi Arabia
Contacts
CONTACTBushra k Alharbi
STUDY_CHAIRAbdullah B Alansare, PhD
King Saud University
Outcome results
None listed