Skip to content

Do Different Arousal Levels Affect Pressure Pain Thresholds?

Do Different Emotional Arousal Levels Affect Pressure Pain Thresholds?

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07802444
Acronym
DDEALAPPT
Enrollment
120
Registered
2026-09-03
Start date
2026-10-01
Completion date
2027-05-31
Last updated
2026-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Arousing Positive Emotion, Low Arousing Positive Condition

Keywords

Emotion, Pressure Pain Thresholds

Brief summary

This study examines whether emotional arousal level alone, while maintaining positive emotional valence, can influence pressure pain thresholds (PPTs) in healthy adults. Pain perception is closely linked to emotional processes, and prior research indicates that emotional valence affects PPTs. However, the specific role of arousal level remains unclear. The study aims to isolate arousal by comparing high arousal positive emotion (humor) with low arousal positive emotion (pleasant video), and a no emotion control condition. A total of 120 healthy participants will be randomly assigned to one of three groups: (1) humor induction (high valence, moderate-high arousal), (2) pleasant emotion induction (high valence, low arousal), or (3) mind wandering control. All participants will first view a neutral baseline video to standardize mood. PPTs will be measured bilaterally at the m. trapezius and m. tibialis anterior using a Somedic algometer (1 cm² probe, 30 kPa/s application rate). Three consecutive PPT measurements per site will be averaged. After the emotional induction (2:30 minutes), PPTs will be reassessed at all four sites. Emotional responses will be validated using the Self Assessment Manikin (SAM) scale to measure valence and arousal. The humor video has been validated in earlier studies, whereas the pleasant low arousal video will be validated in a pre study. Inclusion criteria are age ≥18 and fluency in Swedish; exclusion criteria include pain during testing and known neurological disease. The primary objective is to determine whether high arousal with positive valence increases PPTs (hypoalgesia) and whether low arousal with positive valence decreases PPTs (sensitization). Statistical analyses include repeated measures t tests (Bonferroni corrected) and mixed model ANOVA. Nonparametric tests will be used if PPT distributions deviate from normality.

Interventions

BEHAVIORALEmotional high arousing intervention

The high arousing video will be presented for 2.30 minutes.

BEHAVIORALLow arousal intervention

A low arousing positive video will be presented for 2.30 min.

Sponsors

Linnaeus University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* Above 18 years of age, fluent in Swedish.

Exclusion criteria

* Pain anywhere in body during the test session, known neurological disease.

Design outcomes

Primary

MeasureTime frameDescription
Pressure Pain Thresholds will be tested in m. trapezius and m. tibialis anterior using a hand-held algometer.A baseline video is presented and immediately after PPT measurements are conducted. After that the intervention video is presented and immediately after PPT measurements are conducted.Pressure Pain Thresholds will be tested in m. trapezius and m. tibialis anterior bilaterally using a hand-held algometer.
Pressure Pain ThresholdsFrom experiencing the video and two minutes afterPPTs

Contacts

CONTACTHelena Gunnarsson, PhD
helena.gunnarsson@lnu.se+46708432509

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 4, 2026