Skip to content

Evaluation of the Effectiveness of Oral Ozonized Oil Supplementation in Elite Athletes

Evaluation of the Effects of Ozonated Oil Administration on Athletic Performance and Injury Prevention in Elite Athletes.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07801924
Enrollment
33
Registered
2026-09-03
Start date
2024-09-09
Completion date
2025-04-18
Last updated
2026-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscular, Recovery Methods, Strength Endurance

Brief summary

Ozonized oil has anti-inflammatory and antioxidant properties, but its effects on athletic performance remain unclear. This study evaluated whether daily ozonized oil supplementation, combined with training, influences aerobic capacity, anaerobic power, maximal strength, and muscular endurance in elite rugby players over six months

Interventions

DIETARY_SUPPLEMENTOzonized Oil

, the present study aimed to investigate the potential effects of daily oral supplementation with ozonized oil (O3ZONE Sport®) (produced for O3 ZONE LIMITED, Acquaviva, RSM) on physical performance outcomes - aerobic capacity, maximal strength, muscular endurance, and functional fitness - in elite rugby players over a six-month training period.

Sponsors

Universita degli Studi di Genova
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Inclusion criteria were age ≥18

Exclusion criteria

* NA

Design outcomes

Primary

MeasureTime frameDescription
The primary objective was to investigate the effects of ozonated oil administration on athletic performance and injury prevention in a group of 21 rugby athletes, divided into two groups: Experimental group (n=13) vs Control group (n=8)1 yearBruce test: which measures a subject's maximal oxygen consumption (VO2max). VO2max represents the maximum aerobic power, that is, the maximum amount of energy that can be synthesized by the aerobic mechanism in a unit of time.

Secondary

MeasureTime frameDescription
The primary objective was to investigate the effects of ozonated oil administration on athletic performance and injury prevention in a group of 21 rugby athletes, divided into two groups: Experimental group (n=13) vs Control group (n=8)1 yearBronco test: is a 1,200 meter shuttle run designed to measure maximum aerobic speed (MAS) and endurance, primarily used in rugby. The test requires athletes to complete five sets of 20 meter, 40 meter, and 60meter shuttle runs, totalling 1,200 meters as fast as possible

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 4, 2026