Refraction Error, Tomography, Visual Acuity
Conditions
Brief summary
The initial purpose of the study is to determine the true tomographic based age-specific prevalence of keratoconus among Danish patients with Downs Syndrome. If, as expected, the prevalence is sizeable, the next step is to determine the optimal age for screening - considering both sensitivity and specificity as well as the need for early diagnosis in order to preserve a good visual acuity with glasses. Lastly, the overall purpose based on the finding in the study is to evaluate if a tomographic screening program for keratoconus among patients with Downs syndrome is beneficial in Denmark. In addition, a sub-study will further have the purpose to investigate whether patients with Downs syndrome are using optimal correction. With the purpose of generating knowledge about refraction of this specific patient group - independent of whether they are diagnosed with keratoconus or not. The study will invite all persons with a genetic test either prenatal or postnatal showing trisomi 21 / Downs syndrom in Denmark and between the age og 10 and 20 years of age.
Interventions
None listed
Sponsors
University of Aarhus
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
10 Years to 20 Years
Healthy volunteers
No
Inclusion criteria
* genetic diagnosis of trisomi 21 / downs syndrome
Exclusion criteria
* inability to have cornea tomography performed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Corneal tomography | Baseline, single time point when the study participants are included in the study | Corneal tomography to determine if the participant has keratoconus or not |
Countries
Denmark
Contacts
PRINCIPAL_INVESTIGATORSashia Bennett, MD, PhD
University of Aarhus
Outcome results
None listed