EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
Conditions
Brief summary
Objective: To compare efficacy of topical tranexamic acid versus standard postop care in reducing wound drainage following modified radical mastectomy (MRM). Study Design: Randomized controlled trial. Setting and Duration: Department of General Surgery, Gulab Devi Hospital, over period of six months. Methods: Total of 60 patients undergoing MRM were enrolled and randomly allocated into two groups, with 30 patients in each group. Group I received topical tranexamic acid applied to surgical wound, while Group II received standard postop care without tranexamic acid. Objective was to assess total wound drainage ( in ml), duration of drainage (in days) and frequency of wound infection among two group. Data were analyzed using SPSS version 26, and p-value ≤0.05 was considered statistically significant.
Interventions
TRANEXAMIC acid topical application
Sponsors
Gulab Devi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
1\. All patients diagnosed with ductal or lobular breast carcinoma for whom MRM is indicated.
Exclusion criteria
1. History of thromboembolic events. 2. Patients with coagulation disorders. 3. Currently on anticoagulant therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wound drainage | 6 months | To compare efficacy of topical application of tranexamic acid compared to standard postoperative care after MRM in terms of duration of wound drainage |
Countries
Pakistan
Outcome results
None listed