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The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis

The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis: A Randomized Controlled Study

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07800156
Enrollment
26
Registered
2026-09-02
Start date
2026-09-02
Completion date
2027-05-02
Last updated
2026-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athlete, Healthy Adult

Brief summary

The purpose of this study is to investigate the effects of an acute aerobic exercise on irisin, klotho, sirtuin-1, and BDNF levels in the healthy adults. The findings will help understand the physiological impacts of exercise on these biomarkers.

Interventions

BEHAVIORALAerobic exercise

Acute aerobic exercise until exhaustion

Sponsors

Cemre Didem Eyipinar
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* Being between the ages of 18 and 45 * Being in good health and having no diagnosis of any chronic disease * Not having taken regular medication within the last 4 weeks * Voluntary participation and providing written informed consent

Exclusion criteria

* Individuals with a history of cardiovascular, endocrine, metabolic, or renal disease * Individuals with a history of active infection, musculoskeletal injury, or severe disability * Individuals with any medical condition that might prevent participation in exercise * Individuals unable to regularly participate in the exercise protocol throughout the study

Design outcomes

Primary

MeasureTime frameDescription
Salivary Irisin LevelBaseline- immediately after exercise and 1 hours after exerciseIrisin concentration will be determined from a saliva sample using the ELISA technique.
Salivary Klotho LevelBaseline- immediately after exercise and 1 hours after exerciseKlotho concentration will be determined from a saliva sample using the ELISA technique.
Salivary Sirtuin LevelBaseline- immediately after exercise and 1 hours after exerciseSirtuin concentration will be determined from a saliva sample using the ELISA technique.
Salivary BDNF LevelBaseline- immediately after exercise and 1 hours after exerciseBDNF concentration will be determined from a saliva sample using the ELISA technique.

Secondary

MeasureTime frameDescription
Saliva Flow RateBaseline- İmmediately after exercise and 1 hour after exerciseIt will be calculated individually by dividing the weight of the saliva collected within one minute by the duration.

Countries

Turkey (Türkiye)

Contacts

CONTACTCemre Didem Eyipınar, PhD
cemreeyipinar@gantep.edu.tr+90 545 264 54 86

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 3, 2026