Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children

Comparison of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia Following Inguinal Hernia Repair: A Randomized Control Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07799311

Enrollment

114

Registered

2026-09-02

Start date

2026-08-28

Completion date

2026-11-28

Last updated

2026-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence Delirium, Anesthesia

Brief summary

This is a clinical study for comparing the efficacy of two drugs i.e propofol and dexmedetomidine in prevention of a group of post operative abnormal behaviours that can occur after sevoflurane anesthesia in children and we will measure this by a special scale which is used to evaluate these behavioural changes.

Detailed description

A randomized clinical trial in which we will compare a single dose propofol with a single dose of dexmedetomodine given at the end of surgery after sevoflurane \_based anesthesia to prevent post operative emergence agitation which is a group of behaviours consisting of confusion , disorientation,hyperactivity and even physical harm to themselves and others. this behavioural response is assessed by a score which is called peadriatric anesthesia emergence delerium scale (PEAD) which consist of 5-itms and 5-point scale ,ranging from not at all to extremely.the total score range from 0 to 20,with higher scores indicating more svere emergence agitation . In this study , the PEAD score will be recorded at 0,5,10,15,and 30 minutes after the child reach the recovery room ,and score greater than 10 at any of these readings will be taken as emergence agitation or delerium.

Interventions

DRUGpropofol 1mg/kg

1mg/kg propofol given 10 minutes before the end of surgery

DRUGDexmedetomidine

0.3mcg/kg of dexmedetomidine to group D patients will be given after dilution with 10ml of 0.9%saline over 1 min given 10 minutes before extubation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

2 Years to 12 Years

Healthy volunteers

Yes

Inclusion criteria

1- age 2-12 years 2-elective inguinal hernia repair under general anesthesia \-

Exclusion criteria

1. congenital anomalies 2. allergic to study medications 3. chronic pain syndromes 4. malnourishment -

Design outcomes

Primary

Measure	Time frame
Emergence Delirium PAED score	PAED score will be calculated upon arrival in Post Anesthesia care unit then at 5,10,15,30 minutes interval

Countries

Pakistan

Contacts

CONTACTMuhammad Haroon Principal Investigator, MBBS, FCPS

haroonanwar22@gmail.com+92-333-5236956

STUDY_CHAIRNaheed Fatima

Head of Department

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 3, 2026