Schizophrenia With Auditory Hallucinations
Conditions
Brief summary
This study aims to investigate the after-effects of high-definition transcranial alternating current stimulation (HD-tACS) with varying parameters on resting-state brain activity in patients with schizophrenia experiencing auditory hallucinations.
Interventions
DEVICEhigh-definition transcranial alternating current stimulation(HD-tACS)
The active intervention consists of high-definition transcranial alternating current stimulation (HD-tACS) delivered using a 4×1 ring configuration (one center electrode surrounded by four return electrodes) over the personalized left or right temporal lobe. The return electrodes deliver one-quarter of the central electrode current with opposite polarity. Stimulation is administered for 90 seconds per condition, with the frequency and current intensity set according to the experimental protocol. A 10-second ramp-up and a 5-second ramp-down period are included in each stimulation condition. The stimulus waveform is sinusoidal. Stimulation is delivered using saline-soaked sponge electrodes. Electrode impedance is maintained below 10 kΩ throughout the stimulation session.
DEVICEsham high-definition transcranial alternating current stimulation(HD-tACS)
The sham intervention consists of high-definition transcranial alternating current stimulation (HD-tACS) delivered using a 4×1 ring configuration (one center electrode surrounded by four return electrodes) over the personalized left or right temporal lobe. The return electrodes deliver one-quarter of the central electrode current with opposite polarity. To mimic the sensory experience of active stimulation, the sham condition includes a 10-second ramp-up and a 5-second ramp-down period at 0.4 mA and 140 Hz, with no current delivered during the intervening 90-second period.
Sponsors
Shanghai Mental Health Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 to 65 years; * Meet the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); * Adequate verbal communication skills; * At least one auditory hallucination episode within the past week; * Willing to participate in the study and able to complete all trial procedures.
Exclusion criteria
* History of neurological disorders, severe physical illness, traumatic brain injury, or craniotomy; * History of epileptic seizures or other neuropsychiatric disorders; * At risk for suicide, self-injury, or impulsive behavior.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Beta2-band EEG power at the stimulation site | 180-second recording after each 90-second stimulation | Changes in EEG power(dB) in beta2 band within different frequency band measured at the temporal lobe during the 180-second resting-state EEG recording immediately following each stimulation condition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Alpha-band EEG power at the stimulation site | 180-second recording after each 90-second stimulation | Changes in EEG power(dB) in alpha band within different frequency band measured at the temporal lobe during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Delta-band EEG power at the stimulation site | 180-second recording after each 90-second stimulation | Changes in EEG power(dB) in delta band within different frequency band measured at the temporal lobe during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Theta-band EEG power at the stimulation site | 180-second recording after each 90-second stimulation | Changes in EEG power(dB) in theta band within different frequency band measured at the temporal lobe during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Gamma-band EEG power at the stimulation site | 180-second recording after each 90-second stimulation | Changes in EEG power(dB) in gamma band within different frequency band measured at the temporal lobe during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Beta2-band functional connectivity measured by EEG wPLI | 180-second recording after each 90-second stimulation | Beta2-band functional connectivity between predefined EEG electrodes, quantified using the weighted Phase Lag Index (wPLI), during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Alpha-band functional connectivity measured by EEG wPLI | 180-second recording after each 90-second stimulation | Alpha-band functional connectivity between predefined EEG electrodes, quantified using the weighted Phase Lag Index (wPLI), during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Delta-band functional connectivity measured by EEG wPLI | 180-second recording after each 90-second stimulation | Delta-band functional connectivity between predefined EEG electrodes, quantified using the weighted Phase Lag Index (wPLI), during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Theta-band functional connectivity measured by EEG wPLI | 180-second recording after each 90-second stimulation | Theta-band functional connectivity between predefined EEG electrodes, quantified using the weighted Phase Lag Index (wPLI), during the 180-second resting-state EEG recording immediately following each stimulation condition. |
| Gamma-band functional connectivity measured by EEG wPLI | 180-second recording after each 90-second stimulation | Gamma-band functional connectivity between predefined EEG electrodes, quantified using the weighted Phase Lag Index (wPLI), during the 180-second resting-state EEG recording immediately following each stimulation condition. |
Countries
China
Outcome results
None listed