Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery
Conditions
Keywords
propofol , Dexmedetomidine ,Minimally Invasive Cardiac Valve Surgery
Brief summary
Propofol-Dexmedetomidine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery: Effects on Anesthetic Consumption, perioperative outcomes, and Early Recovery
Detailed description
This prospective, randomized, double-blind study was conducted to evaluate the effect of dexmedetomidine as an adjunct to propofol-based anesthesia in patients undergoing minimally invasive cardiac valve surgery. Patients were randomly allocated to receive either dexmedetomidine or placebo in addition to standard propofol-based anesthesia. The primary outcome was total propofol consumption during surgery. Secondary outcomes included intraoperative hemodynamic parameters, anesthetic and recovery characteristics, and postoperative outcomes.
Interventions
Thirty patients will receive a continuous infusion of propofol at a rate of 2 mg/kg/h and 50 cc 0.9% sodium chloride solution infused at a rate of 0.4 µg/kg/h (used as a placebo).
DRUGpropofol and dexmetomidine
patients will receive a continuous infusion of propofol at a rate of 2 mg/kg/h in addition to dexmedetomidine at a rate of 0.4 µg/kg/h.
Sponsors
Kafrelsheikh University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. patients belonging to American Society of Anesthesiologists (ASA) class I or II 2. patients scheduled for minimally invasive cardiac valve surgery.
Exclusion criteria
1. patient more than 60 years 2. patients having neurological/psychological disorders, 3. patient having severe systemic disorders (renal/hepatic dysfunction and severe respiratory disorder), 4. patient with history of allergy to the study drugs, 5. patient with left ventricular ejection fraction \< 40%,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total intraoperative isoflurane consumption between propofol dexmedetomidine anesthesia and propofol anesthesia alone under entropy-guided anesthesia | Time Frame: From induction of anesthesia until discontinuation of anesthesia; total isoflurane consumption will be recorded at the end of surgery. | Total intraoperative isoflurane consumption Description: The total amount of isoflurane consumed during anesthesia will be compared between patients receiving propofol-dexmedetomidine anesthesia and those receiving propofol anesthesia alone under entropy-guided anesthesia. Isoflurane consumption will be assessed from induction of anesthesia until discontinuation of anesthesia and measured as the total volume consumed. (ML\\MIN) |
Contacts
CONTACTDonia Hany Hany, MD
Outcome results
None listed