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This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload

Comparing Lung Ultrasonography and Left Ventricular Outflow Tract Velocity Time Integral for Early Detection of Fluid Overload After Fluid Resuscitation in Septic Shock Patients

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07797751
Acronym
lvotvti
Enrollment
30
Registered
2026-09-01
Start date
2026-08-15
Completion date
2026-12-30
Last updated
2026-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fluid Reponsiveness, Septic Shock

Keywords

Septic, fluid, response, ultrasound

Brief summary

Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.

Detailed description

Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral. To decrease the incidence of fluid accumulation syndrome. * To assess the feasibility and time required for each imaging modality in guiding fluid resuscitation. * Comparison of the time required for point-of-care lung ultrasound versus LVOT-VTI to guide fluid resuscitation decisions. To assess the sensitivity and specificity of lung ultrasonography (B-Lines) in predicting fluid non responsiveness in septic shock patients

Interventions

None listed

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Adult patients aged ≥ 18 years with septic shock. 2. Mean arterial pressure (MAP) \<65 mmHg. 3. Need fluid resuscitation.

Exclusion criteria

1. Patient \<18 years. 2. Refusal of patient or relative to participate in the study. 3. Other types of shock. 4. Morbid obesity. 5. Valvular heart disease including severe aortic and mitral stenosis) and (severe aortic and mitral regurgitation). 7.Patients with heart failure with preserved or reduced Ejection fraction. 8.Burn patients. 9.End stage renal disease with regular hemodialysis patient. 11.Patients with massive pleural effusion. 12. patients with septic cardiomyopathy. 13.patients with massive ascites. 14. patient on high positive end expiratory pressure or with acute respiratory distress syndrome (ARDS). 15. Patients with right ventricular failure \& pulmonary hypertension. 16. Patients with pneumonia and interstitial lung diseases. 17. Ventilated patients. 18. Poor echo window patients.

Design outcomes

Primary

MeasureTime frame
Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral versus lung ultrasound12 hours
Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral ursus lung ultrasound.12 hours

Contacts

CONTACTMohamed ElSherbini El-Saedy, bachelor
mmelsherbini365@gmail.com+010037407868
STUDY_DIRECTORWalid Youssef Kamel, Associate Professor

AinShams university

STUDY_DIRECTORHeba Mohamed El-Serwi, Professor

AinShams university

STUDY_DIRECTORMarwa Mamdoud El-Far, Assistant Professor

AinShams university

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 2, 2026