Epilepsy
Conditions
Keywords
epilepsy, cognitive task, stereoelectroencephalography
Brief summary
As part of the clinical management of certain severe, drug-resistant forms of epilepsy, it is necessary to implant electrodes in the brain to identify the epileptic network prior to potential neurosurgical resection of the source zones. This standardized procedure, known as Stereo-Electroencephalography (SEEG), was developed in France in the 1960s. The electrodes remain implanted for several days-typically two weeks-while awaiting spontaneous epileptic seizures. During this period, the patient remains hospitalized, and their electroencephalographic activity is recorded around the clock. Patients can be asked to perform cognitive tasks (such as tasks involving memory, attention, vision, language, and decision-making) while awake or asleep; the results can then be correlated with the intracerebral electroencephalographic activity recorded simultaneously as part of their clinical care. This approach makes it possible to capture the electrophysiological signatures of specific cognitive processes, thereby enabling researchers to: 1) create a brain map of electrophysiological signatures, 2) improve standard models of cognitive function, and 3) study the dysfunction of these processes in epilepsy.
Interventions
OTHERCognitive tasks in the form of questionnaires
During their hospitalization for SEEG, patients will perform cognitive tasks to assess memory, vision, attention, language, and decision-making.
Sponsors
University Hospital, Toulouse
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patient with drug-resistant focal epilepsy undergoing SEEG evaluation as part of the pre-surgical workup for epilepsy * Intellectual capacity sufficient to perform cognitive tasks, receive information about the study procedure, and understand the information sheet
Exclusion criteria
* Patients already participating in another research project that prohibits participation in another study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Construction of a database of electrophysiological signatures of various cognitive functions | 3 weeks after the inclusion | Correlation of performance on a task involving a neurocognitive process with characteristics of brain activity recorded during the task (electrophysiological signature) using intracranial stereo-electroencephalography (SEEG) electrodes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Determine whether a given brain region is dysfunctional in certain epileptic patients by comparing it with the atlas of normal physiological signatures. | 3 weeks after the inclusion | Identification of a dysfunctional brain region in an epileptic patient if the electrophysiological signature differs significantly from that expected based on the atlas. |
| Evaluation of the impact of epilepsy on these electrophysiological signatures | 3 weeks after the inclusion | Significant impact of the patient's epilepsy on the normal electrophysiological signature expected during certain cognitive processes. |
Countries
France
Contacts
CONTACTJonathan Curot, PHD
Outcome results
None listed