Skin Brightening
Conditions
Brief summary
This is a double-blind randomized, complete block design study on Chinese population, expecting approximately 18 participants recruited and at least 10 participants to complete the whole 9-week study. The study test sites will receive a single 2MED UV radiation .
Interventions
OTHERSMR 1
Cosmetic skin brightening product to be applied to defined test site
OTHERSMR 2
Cosmetic skin brightening product to be applied to defined test site
OTHERSMR 3
Cosmetic skin brightening product to be applied to defined test site
OTHERSMR 4
Cosmetic skin brightening product to be applied to defined test site
OTHERSMR 5
Cosmetic skin brightening product to be applied to defined test site
OTHERPro-Derma 1
Cosmetic skin brightening product to be applied to defined test site
OTHERPro-Derma 2
Cosmetic skin brightening product to be applied to defined test site
OTHERPro-Derma 3
Cosmetic skin brightening product to be applied to defined test site
OTHERPro-Derma 4
Cosmetic skin brightening product to be applied to defined test site
OTHERPro-Derma 5
Cosmetic skin brightening product to be applied to defined test site
OTHERThiamidol
Cosmetic skin brightening product to be applied to defined test site
Sponsors
Unilever R&D
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy Chinese female or male, aged from 18 to 50 years old (both inclusive). * Participants in good health condition as per the health history questionnaire with no disease state or physical condition that the investigator believes could interfere with the interpretation of the data. * Participant is able to read, understand and sign an appropriate informed consent form indicating his willingness to participate. * ITA° range 10-42°; Skin type III and IV included and can tolerance 2MED radiation. * No history of allergic diseases or allergies to cosmetics, UV light and other topical preparations. * No history of photosensitive diseases and no recent use of medications that affect photosensitivity. * The test area skin (back) should be free of birthmarks, inflammation, scars, excessive hair, etc. * No cuts, abrasions, fissures, wounds, lacerations on the test site (back). * Participants must understand the trial process, voluntarily participate in the study, and sign a written informed consent form. * Willing to attend the study center twice daily for product application during the study period and complete all visits.
Exclusion criteria
* Study participants are employees of Sponsor or CRO. * The study participants participated in test involving the test site within 2 months prior to the start of this test or are currently participating in such tests. * Study participants had any other visible signs of local irritation, erythema, or skin disease on the visible parts of the body. * Study participants consider they are prone to breakouts and/or sensitive skin. * Study participants had a chronic illness or had major surgery in the past year. * Study participants were receiving any skin treatments on the test sites. * Study participants had allergies or sensitivities to cleansing products, creams/emulsion, costume jewelry, or other things. * Female study participants were pregnant/breastfeeding or planning to become pregnant during the trial (study participants self-declared at screening visits). * Study participants took medication for any condition, which the researchers believe may have affected the interpretation of the data. * Study participants had a history of psoriasis, eczema, atopic dermatitis, severe acne, etc. Or have other chronic systemic diseases. * Study participants had received oral or topical corticosteroids and other anti-inflammatory drugs within the last 1 month. * Study participants used tartaric acid, salicylic acid and any other products or drugs that affect skin colour (such as hydroquinones) within the last 2 months. * Study participants used retinoic acid preparations or aesthetic treatment such as chemical stripping, laser, pulsed light, etc. in the test site in the past three months. * Study participants were inevitably exposed to prolonged sunlight. * Clinical evaluation considers that participants are not suitable for the test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| L*, a*, b*, ITA | From 1-week pre-treatment phase to end of study at 8 weeks | Measure skin color (L\*, a\*, b\* values, calculate ITA°) on the back test areas using Spectrophotometer, CM-26d. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hydration and barrier function | From 1-week pre-treatment phase to end of study at 8 weeks | Measure skin hydration on the back test areas using Corneometer, CM825. Measure TEWL on the back test areas using Vapometer . |
Contacts
CONTACTSunny Du
Outcome results
None listed