Ephedrine, Norepinephrine
Conditions
Keywords
preeclamptic patients, spinal induced hypotension, norepinephrine, ephedrine
Brief summary
intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients
Detailed description
A Comparative study of intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients
Interventions
DRUGGroup 1 (P)
receive bolus dose of phenyelepherine 75 ug
DRUGGroup 2( N)
Group 2( N) will receive bolus dose of noradrenaline 4 ug
DRUGGroup 3( E)
Group 3( E) will receive bolus dose ephedrine 4 mg
Sponsors
Minia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Preeclamptic pregnant female * ASA II and III * singleton or twin pregnancies will be scheduled for caesarean delivery * diagnosis of preeclampsia as a new onset of hypertension and proteinuria.
Exclusion criteria
* chronic hypertension, labor or failed trial of labor, * body mass index ≥40 kg/m2 , * resting heart rate \<60 bpm, eclampsia, * known fetal anomalies, contraindications to spinal anesthesia, abruption placentae, and cord prolapas.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate changes | every 3 minutes till 40 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure | every 3 minutes till 40 minutes |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATORAli Ali, Assistant lecturer
Assistant lecturer
Outcome results
None listed