Hemodynamic Response to Laryngoscopy and Tracheal Intubation
Conditions
Keywords
magnesium suplhate, lignocaine, endotracheal intubation, hemodynamic response, laryngoscopy
Brief summary
This study will compare intravenous magnesium sulfate with intravenous lidocaine for reducing the cardiovascular response to endotracheal intubation in adult patients undergoing general anesthesia. Eligible participants will receive either magnesium sulfate or lidocaine before endotracheal intubation. Heart rate and blood pressure will be recorded at predefined time points before and after intubation to compare the effectiveness of the two interventions in attenuating the hemodynamic response to laryngoscopy and endotracheal intubation.
Interventions
intravenous magnesium Sulphate 30mg /kg diluted in 100ml normal saline, administered 90 sec before induction of general anesthesia
Sponsors
Lady Reading Hospital, Pakistan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18-70 yrs * male and female patients * patients undergoing elective or emergency procedures under general anesthesia
Exclusion criteria
* pregnancy * anticipated difficult airway
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate 5minutes after endotracheal intubation | 5 minutes after endotracheal intubation |
| systolic blood pressure 5 minutes after endo tracheal intubation | 5 minutes after endotracheal intubation |
| mean arterial pressure 5 minutes after endotracheal intubation | 5 minutes after endotracheal intubation |
Outcome results
None listed