Burn Sepsis, C-Reactive Protein, Diagnostic Role, Early Detection, Highly Sensitive, Procalcitonin, Prognostic Role
Conditions
Brief summary
This study aimed to evaluate the value of procalcitonin and highly sensitive c-reactive protein as biomarkers for early detection of sepsis in patients with major burns.
Detailed description
Severe burn injuries can cause a marked inflammatory stress response. As the inflammatory state progresses, pro-inflammatory cytokines are continuously released. C reactive protein (CRP) is closely related to the systemic inflammation in its acute phase, as CRP binds to the damaged cell membranes that associates burn injuries and contributes to the associated inflammatory response. Procalcitonin (PCT) a precursor protein for calcitonin, which is synthesized by thyroid C-cells, is yet another biomarker valuable in the sepsis diagnosis.
Interventions
DIAGNOSTIC_TESTMeasurement of Procalcitonin level
Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.
DIAGNOSTIC_TESTMeasurement of c-reactive protein level
Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.
Sponsors
Mansoura University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age from 3 years to 65 years. * Both sexes. * Patients with major burn (2nd and 3rd degrees of burn).
Exclusion criteria
* Patients with unrealistic expectations. * Patients with inhalational burn injury. * Patients with uncompensated chronic disease e.g. hepatic, renal. * Patients with mental or psychological troubles affecting the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of c-reactive protein level | 5 days of burn injury | Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of procalcitonin level | 5 days of burn injury | Two samples were collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days. |
Countries
Egypt
Outcome results
None listed