Functional Food Product

Gastroprotective Effects of Pomegranate (Punica Granatum L.) Peel Powder-Enriched Functional Food in Gastric Ulcer Management

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07789561

Enrollment

Registered

2026-08-27

Start date

2024-02-15

Completion date

2024-05-07

Last updated

2026-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Tests, Liver Function Tests, Ulcer

Keywords

Punica granatum,, Gastric Ulcer, Helicobacter pylori, Functional Foods

Brief summary

Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H. pylori, inflammation, oxidative stress, and gastric ulcer healing in patients with gastric ulcers. Conclusion: PPP-enriched muffins showed potential as a functional dietary intervention for improving antioxidant and anti-inflammatory status and supporting gastric ulcer healing.

Detailed description

Background/Objective: This study investigated the therapeutic potential of pomegranate peel powder (PPP), a polyphenol- and antioxidant-rich ingredient, incorporated into whole-wheat muffins at doses of 1.5 g and 2.5 g for patients with gastric ulcers. The study assessed its potential effects on H. pylori infection, gastric inflammation, oxidative stress, and mucosal healing. Conclusion: PPP-enriched muffins were evaluated as a functional dietary intervention with potential gastroprotective, antioxidant, and anti-inflammatory properties, supporting their possible role in dietary management of gastric ulcers.

Interventions

DIETARY_SUPPLEMENTpomegranate peel powder 1.5 g

Whole wheat muffin enriched with pomegranate peel powder (PPP=1.5 g) + conventional Therapy

DIETARY_SUPPLEMENTpomegranate peel powder 3 g

Whole wheat muffin enriched with pomegranate peel powder (PPP=3g) + conventional Therapy

DIETARY_SUPPLEMENTWhole wheat muffin

Whole wheat muffin

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

40 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Both male and female patients aged 40-60 years with confirmed Helicobacter pylori infection, verified through stool antigen testing along with elevated pepsinogen I and II levels, were included in the study

Exclusion criteria

pregnancy or lactation, history of gastric surgery, and current use of proton pump inhibitors. and use of medication \-

Design outcomes

Primary

Measure	Time frame
Liver Enzymes	9 weeks

Secondary

Measure	Time frame
H.phylori	9 weeks

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 28, 2026