Mechanical Power-Integrated Oxygenation Indices for Predicting Postoperative Pulmonary Complications After Major Abdominal Surgery

Integrating the Ventilator Mechanical Power Into the Oxygenation and Saturation Indices for Prediction of Postoperative Pulmonary Complications After Major Abdominal Surgeries; a Prospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07788313

Enrollment

120

Registered

2026-08-26

Start date

2025-07-01

Completion date

2026-07-12

Last updated

2026-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pulmonary Complications (PPC)

Keywords

ventilator mechanical power, composite indices, oxygenation and saturation indices, Postoperative pulmonary complications (PPC)

Brief summary

The goal of this prospective observational study is to determine whether novel oxygenation and oxygen saturation indices that incorporate total or dynamic mechanical power can predict postoperative pulmonary complications (PPCs) in adults undergoing major abdominal surgery. The main questions it aims to answer are: * How well do OI-MPtot, OI-MPdyn, OSI-MPtot, and OSI-MPdyn predict PPCs within the first 7 days after surgery? * Do these novel indices predict PPCs better than mechanical power (MPtot and MPdyn), conventional oxygenation and saturation indices (OI and OSI), and the preoperative ARISCAT score? * What cutoff values and diagnostic accuracy of the novel indices can be used to identify patients at increased risk of PPCs? Participants will: * Undergo elective open major abdominal surgery under general anesthesia and mechanical ventilation. * Have intraoperative mechanical ventilation parameters recorded hourly during surgery. * Have mechanical power, oxygenation, and oxygen saturation indices calculated from the collected data. * Be followed during their hospital stay and for 7 days after discharge for the occurrence of PPCs, including respiratory infection, respiratory failure, pleural effusion, atelectasis, pneumothorax, bronchospasm, and aspiration pneumonitis. * Have their clinical, surgical, and ventilatory characteristics recorded and compared according to whether PPCs occur.

Interventions

OTHERNo Interventions

The study does not include interventions.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18-60 years old. * Both sexes. * Patients undergoing elective open major abdominal surgeries (abdominal exploration, hepatectomy, gastrectomy) under general anaesthesia and mechanical ventilation at least 2 hours. * ASA- physical status I/II * without any known history of respiratory disease

Exclusion criteria

* Obstructive sleep apnea. * Patients with chronic pulmonary diseases like COPD, asthma, or pulmonary fibrosis. * Patients who have undergone major lung surgery. * Patients dependent on mechanical ventilation or CPAP prior to surgery. * Neurological disorders affecting respiratory function: Conditions like myasthenia gravis or Guillain-Barré syndrome. * Pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of Postoperative pulmonary complications (PPC)	one year	Evaluate and compare the predictive capabilities of newly developed oxygenation and saturation indices, which incorporate MPtot and MPdyn instead of Pmean (OSI-MPtot, OI-MPtot, OSI-MPdyn, OI-MPdyn), for the occurrence of postoperative pulmonary complications (PPCs) within the first seven days following major abdominal surgeries.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 27, 2026