Injectable Platelet-Rich Fibrin, Minimally Invasive, Non-Surgical Technique, Grade II Furcation Defects
Conditions
Brief summary
This study aims to compare the clinical and radiographic effectiveness of injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical therapy (MINST) versus MINST alone in the management of class II furcation defects.
Detailed description
Periodontitis is a multifactorial inflammatory disease that occurs due to the challenge between the host response and specific periodontal pathogens, leading to a gradual destruction of the periodontal supporting tissues over time. Different regenerative approaches have been proposed including guided tissue regeneration (GTR); bone grafts, bioactive agents such as enamel matrix derivative (EMD) and platelet concentrates. Using the minimally invasive nonsurgical technique (MINST) implements magnification with microscope/loupes and delicate instruments, to perform the periodontal debridement with more effective root debridement and less soft tissue trauma. MINST significantly improve the visualization and root decontamination, and at the same time preserve the gingival margin and consequently improve the aesthetic results and tissue stability.
Interventions
Patients will receive minimally invasive non-surgical technique (MINST) alone
PROCEDUREMinimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Patients will receive minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Sponsors
October 6 University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration. * Diagnosis of stage III, grade B periodontitis (according to the AAP/EFP classification 2018) with the presence of class II furcation defect in either the maxillary (buccal) or mandibular arch (buccal or lingual) as determined by clinical evaluation and confirmed by radiographic evaluation. * Gingival margin and interdental bone positioned coronally to the furcation entrance. * Commitment to maintenance visits and follow-up. * Absence of primary endodontic lesions.
Exclusion criteria
* Patients suffering from any systemic diseases that may affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc; * Patients that received periodontal surgical treatments in the past 12 months. * Smoking (current or in past 5 years) * Prolonged treatment with antibiotics or anti-inflammatory agents within 6 months prior to periodontal therapy. * Pregnant and lactating females. * Teeth with hopeless prognosis * Third molars
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Radiographic Bone Fill at the Furcation Site | 6 months after treatment | Radiographic bone fill at the furcation site will be assessed using cone-beam computed tomography (CBCT). The analysis will include measurement of the filled bone volume (FBV) at the furcation area using segmentation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Horizontal Clinical Attachment Level | 6 months after treatment | Horizontal clinical attachment level will be assessed using periodontal probing at baseline and 6 months after treatment. |
| Change in Vertical Clinical Attachment Level | 6 months after treatment | Vertical clinical attachment levels will be assessed using periodontal probing at baseline and 6 months after treatment. |
| Change in Probing Pocket Depth | 6 months after treatment | Probing pocket depth (PPD) will be measured in millimeters from the gingival margin to the base of the periodontal sulcus at six sites per tooth using a UNC-15 periodontal probe. Measurements will be recorded at baseline and 6 months after treatment. |
| Change in Gingival Margin Location | 6 months after treatment | The location of the gingival margin will be assessed by measuring the distance from the cemento-enamel junction (CEJ) to the gingival margin. Measurements will be recorded at baseline and 6 months after treatment. |
| Change in Plaque Index | 6 months after treatment | Plaque index (PI) will be assessed to evaluate oral hygiene status by measuring dental plaque accumulation in areas adjacent to the gingival margin. Plaque index will be recorded at baseline and 6 months after treatment. |
| Change in Bleeding on Probing | 6 months after treatment | Bleeding on probing (BoP) will be assessed by gently inserting a periodontal probe into the gingival sulcus at the base of the interdental papilla and recording the intensity of bleeding after a short delay. BoP will be assessed at baseline and 6 months after treatment. |
Countries
Egypt
Contacts
CONTACTMoustafa A Ahmed, B.D.S
Outcome results
None listed