Macular Hole
Conditions
Keywords
Macular Hole, Full-Thickness Macular Hole, Large Macular Hole, Pars Plana Vitrectomy, Internal Limiting Membrane
Brief summary
This study evaluated the outcomes of surgery for large full-thickness macular holes measuring more than 400 micrometres using the inverted internal limiting membrane flap technique with sulphur hexafluoride (SF6) gas tamponade. The study was conducted at the Department of Ophthalmology, Lahore General Hospital, Lahore. A total of 52 male and female patients aged 52-84 years with full-thickness macular holes were included. All patients underwent 23-gauge pars plana vitrectomy with hyaloidectomy and inverted internal limiting membrane flap surgery after staining with 0.05% Brilliant Blue. Patients were divided into two groups according to postoperative positioning. One group performed postoperative face-down posturing, whereas the other group did not perform face-down posturing. The study examined whether successful closure of large macular holes could be achieved without postoperative face-down positioning after surgery with SF6 gas tamponade. Patients were followed on postoperative days 1, 7, 30, and 90. The main outcome was anatomical closure of the macular hole, which was assessed using optical coherence tomography (OCT). Successful treatment was defined as complete anatomical closure of the macular hole. The outcomes of patients who performed face-down posturing were compared with those who did not perform postoperative posturing to determine whether face-down positioning was necessary following surgery for macular holes larger than 400 micrometres.
Interventions
PROCEDUREMacular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade
Patients underwent 23-gauge pars plana vitrectomy with hyaloidectomy and inverted internal limiting membrane flap surgery with SF6 gas tamponade.
BEHAVIORALFace-Down Postoperative Positioning
Patients performed face-down posturing after surgery according to the postoperative instructions.
BEHAVIORALNo Face-Down Postoperative Positioning
Patients were managed without postoperative face-down posturing.
Sponsors
Lahore General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
52 Years to 84 Years
Healthy volunteers
No
Inclusion criteria
* Gender: male and female * All patient having age between 52-84 years * All the patients with full thickness macular hole * All the patients with written informed consent
Exclusion criteria
* Patients with high myopia. * Patient having age related macular degenerations (AMD). * Patient having any chorioretinal disease or Diabetic retinopathy. * Secondary MH causes * Trauma. * Uveitis. * Cystic macular edema. * Age-related macular degeneration * Glaucoma or ocular hypertension * corneal opacity * Patient with history of previously intraocular or vitrectomy surgery other than uncomplicated cataract surgery. * Patient with history of previous laser photocoagulation. * Presence of traction on the macula (OCT). * Patient with significant media opacity preventing retinal view or poor image quality.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anatomical Closure of the Macular Hole on OCT | 3 months after surgery. | Proportion of participants with complete anatomical closure of the macular hole on optical coherence tomography. |
Countries
Pakistan
Contacts
PRINCIPAL_INVESTIGATORAhmad Fauzan
Lahore General Hospital, Lahore
Outcome results
None listed