Intraoperative Glycemic Variability and Infectious Complications After Liver Transplantation

Intraoperative Glycemic Variability and the Risk of Infectious Complications After Elective Liver Transplantation: A Prospective Cohort Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07786857

Acronym

SUGAR-LT

Enrollment

240

Registered

2026-08-26

Start date

2026-08-01

Completion date

2027-07-30

Last updated

2026-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation (LT)

Keywords

liver transplantation, glycemic variability, postoperative infections, surgical site infection

Brief summary

This study aims to evaluate whether intraoperative glycemic variability (GV) is independently associated with the risk of infectious complications within 30 days after elective liver transplantation. This is an observational study with no intervention beyond standard perioperative care. Glycemic and clinical outcome data will be obtained from routinely collected medical records of patients undergoing liver transplantation at the 2nd Department of Anesthesiology and Intensive Care, Medical University of Warsaw.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age over 18 years * Elective orthotopic liver transplantation

Exclusion criteria

* Liver retransplantation * multi-organ transplantation * Urgent/emergency transplantation * Active infection under antibiotic treatment at the time of surgery * Preoperative systemic inflammatory response syndrome (SIRS) * Incomplete intraoperative glycemic data * Pregnancy * Participation in another interventional study that could affect glycemic control or infection risk

Design outcomes

Primary

Measure	Time frame	Description
Occurrence of at least one infectious complication within 30 days after liver transplantation	30 days	Binary outcome (yes/no), including: pneumonia (clinical, radiological, and microbiological criteria), urinary tract infection (clinical symptoms + positive urine culture), surgical site infection per CDC criteria, sepsis/septic shock per Sepsis-3 criteria.

Countries

Poland

Contacts

CONTACTPaula Dudek, MD

paula.dudek@wum.edu.pl+225992002

Outcome results