Intraoperative Perfusion, Postoperative Troponin Elevation
Conditions
Keywords
Postoperative Troponin Elevation, Geriatric Patients, Major Oncologic Surgery, Intraoperative Perfusion, Troponin, Hemodynamic Variability
Brief summary
This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Intraoperative hemodynamic and perfusion-related parameters will be recorded, and postoperative troponin levels will be assessed to investigate whether intraoperative perfusion changes are associated with myocardial injury. Troponin measurements will be obtained preoperatively and at 24 hours after surgery
Interventions
None listed
Sponsors
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 65 years or older * Undergoing major abdominal oncologic surgery * Availability of preoperative and 24-hour postoperative troponin measurements * Complete intraoperative and postoperative patient monitoring records * Provision of written informed consent
Exclusion criteria
* Age younger than 65 years * Absence of preoperative or 24-hour postoperative troponin measurements * Incomplete intraoperative or postoperative patient monitoring records * Undergoing emergency surgery * Advanced heart failure * ASA Physical Status IV * Pulmonary artery pressure \>40 mmHg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery | Preoperatively and 24 hours after surgery | Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association Between Intraoperative Perfusion Index and Postoperative Troponin Elevation | Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively | Perfusion Index (PI) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative PI values and postoperative troponin elevation at 24 hours after surgery will be evaluated. |
| Association Between Intraoperative Pleth Variability Index and Postoperative Troponin Elevation | Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively. | Pleth Variability Index (PVI) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative PVI values and postoperative troponin elevation at 24 hours after surgery will be evaluated. |
| Association Between Intraoperative Cerebral Oxygen Saturation and Postoperative Troponin Elevation | Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively. | Cerebral oxygen saturation measured by near-infrared spectroscopy (NIRS) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative cerebral oxygen saturation values and postoperative troponin elevation at 24 hours after surgery will be evaluated. |
Countries
Turkey (Türkiye)
Outcome results
None listed