No Disease or Condition is Being Directly Studied, The Focus of the Study in Healthy Volunteers
Conditions
Keywords
Osteopathic Manipulation, Influenza vaccine, Aging, Body composition
Brief summary
The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.
Interventions
In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.
In this intervention, participants will receive osteopathic manipulation 2 days prior to influenza vaccination, the day of influenza vaccination, and 4 days post-influenza vaccination. The OMT will include thoracic inlet myofascial release, pectoral traction, rib raising, doming of the diaphragm, pelvic diaphragm release, popliteal fossa release, plantar myofascial release, passive Miller thoracic pump, liver pump, and spleen pump.
OTHERSham
In this intervention, participants will receive no osteopathic treatments
Sponsors
Lake Erie College of Osteopathic Medicine
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Willing to receive OMT * Willing to receive influenza vaccine * Older than 18 years of age
Exclusion criteria
* Younger than 18 years of age * Pregnancy or lactation * Unwilling to receive the influenza vaccine * Unwilling to receive OMT * Open wounds * Bone fractures * Moderate to severe osteoporosis * Severe COPD * Current/active infections * Mononucleosis infection within past 6 months * Liver cirrhosis * Cancer or metastatic disease * History of DVT, PE, or blood clotting disorder * Individuals taking blood thinning medications, except aspirin * Having a pacemaker or other thoracic medical devices
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hemagglutinin inhibition assay | baseline and 4 weeks post vaccination | Hemagglutinin inhibition assay assess the antibody titers in patient's blood. |
Countries
United States
Contacts
CONTACTDavid Duriancik, Ph.D.
CONTACTIrv Freeman, J.D., Ph.D.
PRINCIPAL_INVESTIGATORDavid Duriancik, Ph.D.
Lake Erie College of Osteopathic Medicine
Outcome results
None listed