Healthy Adult Brain Imaging
Conditions
Keywords
Healthy Chinese Adults, Brain Atlas, Magnetic Resonance Imaging, Multi-Field-Strength MRI
Brief summary
This prospective imaging study aims to construct a multi-field-strength magnetic resonance imaging (MRI) brain atlas for healthy Chinese adults. Healthy volunteers will undergo standardized brain MRI examinations at multiple magnetic field strengths, including 0.55T, 1.5T, 3T, 5T, and 7T. Structural, diffusion, functional, and other quantitative MRI data will be acquired and analyzed. The study will characterize the consistency and differences in brain morphology and imaging measurements across field strengths and establish standardized multi-field-strength brain templates and reference data for healthy Chinese adults.
Detailed description
This is a prospective multi-field-strength neuroimaging study involving healthy Chinese adults. Eligible participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T according to the study protocol. MRI acquisitions include structural imaging, diffusion imaging, functional imaging, and quantitative imaging sequences where applicable. Images will undergo standardized preprocessing, registration, segmentation, and quantitative analysis. Multi-field-strength brain templates will be constructed, and anatomical and functional imaging characteristics will be compared across magnetic field strengths. The study aims to establish normative multi-field-strength MRI reference data and brain atlases for healthy Chinese adults and to evaluate the consistency and field-strength-related differences in brain morphometry, cortical measurements, diffusion characteristics, functional connectivity, and other quantitative MRI parameters.
Interventions
DIAGNOSTIC_TESTMulti-Field-Strength Brain MRI
Participants will undergo standardized brain MRI examinations at 0.55T, 1.5T, 3T, 5T, and 7T. MRI acquisitions include structural, diffusion, functional, and quantitative imaging sequences according to the study protocol. No therapeutic intervention will be administered
Sponsors
Tang-Du Hospital
Xi'an Jiaotong University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 66 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 16 to 66 years. Voluntarily participates in the study and provides written informed consent. No contraindications to MRI examination and able to cooperate with and complete the MRI examinations. Female participants must not be pregnant. No current or previous clinical diagnosis of severe neurological or psychiatric disorders, such as schizophrenia, dementia, epilepsy, or severe sequelae of traumatic brain injury. No obvious intracranial lesions or structural abnormalities identified on routine MRI examination.
Exclusion criteria
* Presence of contraindications to MRI examination, including MRI-incompatible implanted metallic or electronic devices, cochlear implants, cardiac pacemakers, intracranial metallic clips, or similar devices. Severe claustrophobia preventing completion of the MRI examination. Pregnancy. Current or previous clinical diagnosis of severe neurological or psychiatric disorders. History of severe head trauma, brain tumor, stroke, brain surgery, or other conditions that may substantially affect brain structure or function. MRI data of insufficient quality for analysis due to marked discomfort, excessive head motion, or other causes during the examination.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional Gray Matter Volume Across MRI Field Strengths | From enrollment through completion of all scheduled multi-field-strength MRI examinations, up to 12 months | Regional gray matter volumes will be quantified from standardized structural MRI data and compared across 0.55T, 1.5T, 3T, 5T, and 7T MRI acquisitions. |
Countries
China
Contacts
CONTACTZiheng Zhou
Outcome results
None listed