China Glomerulonephritis Kidney Transplant Recipient Cohort: A Prospective Multicenter Observational Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07783737

Enrollment

300

Registered

2026-08-25

Start date

2026-09-24

Completion date

2030-07-31

Last updated

2026-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glomerulonephritis Kidney Transplant

Keywords

glomerulonephritis, GN

Brief summary

This is a prospective observational study aimed at establishing a prospective observational cohort of patients with a confirmed diagnosis of glomerulonephritis (GN) before kidney transplantation in China. Information will be collected on the epidemiology of GN recurrence after kidney transplantation, as well as the outcomes and treatment of the primary disease following kidney transplantation, to provide evidence for subsequent clinical studies, drug development, and translational research. Approximately 300 patients with a confirmed diagnosis of GN before transplantation will be prospectively enrolled. Clinical data will be collected during screening, kidney transplantation, and a 3-year post-transplant follow-up. The frequency of follow-up visits is every 3 months in the 1st year after transplantation, and every 6 months during the 2nd to 3rd years, with a total of 8 follow-up visits. The study will be conducted at 10 sites across China.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years. * Diagnosed with primary GN based on clinical guidelines and/or expert consensus * Successfully matching completed and confirmed to be scheduled for kidney transplantation.

Exclusion criteria

* History of organ transplantation or planned multiple organ transplantation. * Complicated with malignancy. * Failure to undergo kidney transplantation for any reason. * Unable to provide written informed consent form (ICF).

Design outcomes

Primary

Measure	Time frame	Description
To assess the incidence of GN recurrence after kidney transplantation and its influencing factors	3-year follow-up	Incidence of GN recurrence after kidney transplantation

Secondary

Measure	Time frame	Description
To assess other clinical events after kidney transplantation and their associated factors	3-year follow-up	incidence and time to rejection

Contacts

CONTACTAstraZeneca Clinical Study Information Center

information.center@astrazeneca.com1-877-240-9479

Outcome results