Biochemical Factors in Patients With and Without Bruxism

The Evaluation of Biochemical Factors in Bruxist and Non-Bruxist Patients: Case Control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07783685

Enrollment

Registered

2026-08-25

Start date

2023-05-01

Completion date

2024-02-01

Last updated

2026-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bruxism

Keywords

Bruxism, vitamin D, Parathyroid hormone, Calcium, Albumin

Brief summary

This observational case-control study aimed to compare biochemical factors related to calcium metabolism between adults with and without bruxism. Participants were classified into bruxism and control groups based on self-reported bruxism behaviors assessed using the BRUX Scale together with standardized clinical examination findings. Serum vitamin D, parathyroid hormone (PTH), calcium, albumin, and albumin-corrected calcium levels were evaluated and compared between the two groups. The study aimed to determine whether these biochemical parameters differ between individuals with and without bruxism and to provide further insight into their potential relationship with bruxism

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Age 18 years or older. American Society of Anesthesiologists (ASA) physical status I or II. Availability of biochemical laboratory results, including serum vitamin D, parathyroid hormone (PTH), calcium, and albumin, obtained within the previous 6 months. Agreement to participate in the study.

Exclusion criteria

Use of medications affecting vitamin D metabolism. Severe malocclusion. Complete or partial edentulism. Active dental or periodontal pain. History of jaw trauma. History of orthognathic surgery. History of temporomandibular joint (TMJ) surgery. Congenital craniofacial anomalies. Psychiatric disorders. Systemic diseases affecting bone metabolism.

Design outcomes

Primary

Measure	Time frame	Description
Serum Vitamin D,calcium,albumin and PTH level	Within 6 months before study assessment	Serum 25-hydroxyvitamin D \[25(OH)D\], calcium, PTH and albumin levels were obtained from available laboratory records and compared between participants with and without bruxism.

Countries

Turkey (Türkiye)

Outcome results