Dry Eye Disease (DED), Fuchs Endothelial Corneal Dysfunction, Keratoconus, Lasik Eye Surgery, Open Angle Glaucoma (OAG)
Conditions
Keywords
cornea, biomechanics, brillouin microscopy
Brief summary
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
Detailed description
Our long-term goal is to establish a direct, accurate, and clinically viable method for measuring corneal hydration, enabling earlier detection, more precise diagnosis, and improved management of corneal diseases and postoperative complications. The objective of this study is to develop and validate Brillouin based hydration mapping as a diagnostic tool to quantify water content in the cornea across healthy individuals and patients with diverse ocular conditions. Our central hypothesis is that spatially resolved Brillouin frequency shifts can reveal disease-specific hydration profiles that are not detectable through conventional thickness-based methods. This hypothesis is based on recent evidence from our group demonstrating that Brillouin microscopy is sensitive to hydration. The rationale for this research is that Brillouin-based hydration maps will offer an unprecedented, morphology-independent metric of corneal fluid balance, which could improve clinical decision-making in a range of pathologies.
Interventions
None listed
Sponsors
Massachusetts General Hospital
Massachusetts Eye and Ear Infirmary
National Eye Institute (NEI)
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers with normal eyes * Visual acuity between +2 to -6 diopters
Exclusion criteria
* History of refractive or cataract surgery * History of ocular disease * Active non-ophthalmic systemic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects to successfully complete Brillouin measurement without serious unanticipated adverse events related to application of the device. | Through completion of the single study visit, approximately 1-2 hours | Number and percentage of enrolled subjects who complete the single Brillouin imaging session without experiencing a serious unanticipated adverse event related to the investigational Brillouin Ocular Scanner, as determined by study staff monitoring during and immediately following the imaging procedure. |
Countries
United States
Contacts
CONTACTSoyeon (Selina) Ahn, PhD
CONTACTSeok-Hyun Yun, PhD
PRINCIPAL_INVESTIGATORSeok-Hyun Yun, PhD
Massachusetts General Brigham
Outcome results
None listed