Duchene Muscular Dystrophy
Conditions
Keywords
Duchene Muscular Dystrophy, postural stability, whole body vibration, gravity force stimulation, children
Brief summary
this study aimed to mention Does whole-body vibration training or gravity-force stimulation produce greater improvements in postural stability among children with Duchenne Muscular Dystrophy?
Detailed description
Duchenne Muscular Dystrophy (DMD) is a progressive X-linked neuromuscular disorder characterized by muscle fiber degeneration due to mutations in the dystrophin gene (Birnkrant et al., 2018). As muscle weakness advances, children with DMD experience impaired postural control, reduced balance function, and increased risk of falls, all of which significantly contribute to limitations in daily activities and loss of independence (Ricotti et al., 2016). Early therapeutic interventions are essential to slow functional decline and promote motor stability for as long as possible. Whole-body vibration (WBV) has emerged as a potential modality to enhance neuromuscular activation, proprioception, and balance in individuals with muscle weakness or neurological impairments. Studies suggest that low-frequency WBV can improve muscle spindle sensitivity, postural reactions, and balance performance in pediatric and neuromuscular populations (Brunetti et al., 2015; Saquetto et al., 2015). Although research involving children with DMD is limited, preliminary evidence indicates that WBV may transiently enhance motor function without excessive muscle strain. Gravity-force stimulation (GFS)-often delivered through tilt platforms, vertical acceleration devices, or graded gravitational loading-has been proposed as another means to stimulate proprioceptive pathways and increase postural control. GFS can enhance sensory input from weight-bearing structures and may promote improved equilibrium response strategies in children with neuromotor impairments (Bates & Hanson, 2019). However, its application specifically in DMD remains under-studied, and direct comparisons with WBV have not been adequately explored.
Interventions
PROCEDUREforce gravity stimulation
Thirty children received: • Gravity-Force Stimulation (GFS), which included: * Exercises will be designed to enhance postural control and trunk stability while exposed to controlled gravitational loading. * Active or active-assisted stabilization exercises performed while experiencing graded gravitational forces. * Arm exercises performed with the trunk stabilized to challenge neuromuscular control under increased gravitational demand. * Trunk mobilization exercises (in sitting and lying positions) performed under conditions simulating increased gravitational load. * Functional reaching activities with varied ranges of shoulder elevation, supported by the physiotherapist to ensure proper control during gravitational stimulation.
PROCEDUREwhole body vibration
we use vibrating platform •
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
6 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
* Children diagnosed with Duchenne Muscular Dystrophy (DMD). * Age between 6 and 10 years. * Lower extremity and trunk muscle strength graded at least 3+, based on the manual muscle testing criteria. * Ability to move the upper and lower limbs within functional limits without severe joint restriction. * Ability to walk independently without assistive devices, corresponding to Levels I and II of the Ambulation Function Classification System for DMD (AFCSD).
Exclusion criteria
* Presence of cardiopulmonary dysfunction or congenital or acquired skeletal abnormalities that may interfere with participation. * History of lower-limb surgical procedures. * Neurological conditions affecting balance or gait, or evidence of poor motor development not attributable to DMD. * Behavioral disorders that would prevent cooperation during assessment or intervention sessions. * Overweight status, defined as a body mass index (BMI) greater than 25 kg/m²
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| abdominal muscle thickness | 3 months | measure the abdominal muscle thickness |
| postural stability | 3 months | • BIODEX MEDICAL SYSTEM used for assessment of postural stability and balance |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATORMostafa S. Ali
Cairo University
Outcome results
None listed