Bicarbonate HD Study

Factors Affecting Bicarbonate Levels In Patients On Haemodialysis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07779200

Enrollment

100

Registered

2026-08-21

Start date

2026-05-12

Completion date

2026-08-01

Last updated

2026-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CKD on Hemodialysis Patients, Metabolic Acidosis

Brief summary

The primary goal of this single centre observational study is to look at factors that affect serum bicarbonate levels in patients on maintenance dialysis. This will be done by collecting demographic information, relevant medical history, dialysis history, potential renal acid load from diet by recording different foods consumed over 2 days in a food diary and bicarbonate levels at 3 intervals, pre and post dialysis session 1 and pre dialysis session 2. Bicarbonate levels are of significant interest as an indicator of metabolic acidosis in CKD dialysis patients. This study will allow us to understand the efficacy of different dialysis modalities in controlling bicarbonate levels. It will also enable us to understand the idea of individualizing dialysis for patients in terms of not using a standard concentration of dialysate for all patient undergoing dialysis in this center.

Detailed description

Cross sectional study

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 years and above. * Ability to give informed consent. * End Stage Renal Disease established on maintenance dialysis for at least 3 months. * Patients on dialysis 3 times a week

Exclusion criteria

* Inability to give informed consent * Patients with acute kidney injury * Patients with severe COPD

Design outcomes

Primary

Measure	Time frame	Description
Change in serum bicarbonate levels in patients on haemodialysis	3 months	Serum bicarbonate concentration measured across two dialysis sessions (HD1 and HD2) measured as Pre HD1, Post HD2 and Pre HD2.

Secondary

Measure	Time frame	Description
Dietary Acid Load	~ 3 months	Potential renal acid load
Volume of Haemodiafiltration	3 months	Haemodiafiltration volume delivered
Indicators of dialysis dose	3 months	Pre HD1 and Post HD1 serum urea

Countries

United Kingdom

Contacts

CONTACTEnric Vilar

enric.vilar@nhs.net01438 284230

CONTACTSimran Sorathia

simran.sorathia@nhs.net01438 284230

Outcome results