Immunohistochemical Expression of Cyclin D1 in Oral Squamous Cell Carcinoma: Relationship With Clinicodemographic and Histopathological Features

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07778615

Enrollment

Registered

2026-08-21

Start date

2017-01-01

Completion date

2026-06-01

Last updated

2026-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Squamous Cell Carcinoma (OSCC)

Keywords

Oral Squamous Cell Carcinoma, Cyclin D1, Immunohistochemistry, Labelling index

Brief summary

Oral squamous cell carcinoma is a major public health problem , especially in West Asian countries. Cyclin D1 accelerates cell cycle and thus may be implicated in uncontrolled cellular proliferation and tumor progression.

Detailed description

Oral squamous cell carcinoma is a major public health problem in different parts of the world. Despite marvelous improvement in treatment modalities -surgical approaches, chemotherapy and radiotherapy- the overall survival ad disease-free survival remain unchanged. so, there a need for studying tumor biology and micro environment. Cyclin D1 is a protein which enhances cell cycle through binding with cyclin-dependent kinases. Over expression of Cyclin D1 may by responsible for the aggressive behavior of oral squamous cell carcinoma through uncontrolled cellular proliferation. in current study, we have detected Cyclin D1 expression in 34 cases of oral squamous cell carcinoma. We detected relationship between intensity of expression and certain parameters as tumor grade, lymphovascular and perineural invasion.

Interventions

BIOLOGICALimmunohistochemical expression of Cyclin D1 on oral squamous cell carcinoma tissue sections

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* patients with oral squamous cell carcinoma.

Exclusion criteria

* patients with oral carcinoma other than squamous cell carcinoma. * patients who received pre-operative radiotherapy. * patients with inadequate clinical data.

Design outcomes

Primary

Measure	Time frame	Description
immunohistochemical expression of Cyclin D1 in Oral Squamous Cell Carcinoma	6 months	detection of both intensity staining and tumor cells percentage of Cyckin D1 in studied cases of Oral Squamous Cell Carcinoma, and then relate intensity and percentage of Cyclin D1 with patients' ages, sexes, tumor grade, tumor site , lymphovascular invasion and perineural invasion.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 22, 2026