Association of Maternal Thyroid Function and Anxiety With Fetal Cardiotocography Parameters in High-Risk Pregnancies

Association Between Maternal Thyroid Functions, Anxiety Levels, and Fetal Cardiotocography Parameters in High-Risk Pregnancies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07774949

Enrollment

150

Registered

2026-08-19

Start date

2026-03-27

Completion date

2028-12-01

Last updated

2026-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High-risk Pregnancy

Keywords

High-risk pregnancy, Maternal anxiety, Thyroid dysfunction, Cardiotocography, Beck Anxiety Inventory

Brief summary

This prospective observational study aims to investigate the association between maternal thyroid function, maternal anxiety levels, and fetal cardiotocography parameters in high-risk pregnancies. Pregnant women at 32 weeks of gestation or later who are followed in the perinatology outpatient clinic for high-risk pregnancy will be included. Maternal thyroid function test results, including thyroid-stimulating hormone (TSH) and free thyroxine (fT4), obtained as part of routine clinical care will be recorded. Maternal anxiety will be assessed using the Beck Anxiety Inventory. Fetal well-being will be evaluated using a routine 20-minute non-stress test (NST), including baseline fetal heart rate, accelerations, reactivity, and the presence of decelerations. The associations between maternal anxiety scores, thyroid hormone levels and thyroid status, and fetal cardiotocography parameters will be analyzed. Sociodemographic and obstetric characteristics will also be evaluated in relation to these parameters.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Singleton pregnancy at 32 weeks of gestation or later * Pregnancy being followed as a high-risk pregnancy * Age between 18 and 45 years * Availability of routine thyroid function test results and non-stress test assessment * Ability and willingness to provide written informed consent

Exclusion criteria

* Gestational age below 32 weeks * Multiple pregnancy * Fetal conditions that may affect interpretation of the non-stress test tracing * Acute maternal infection * Presence of an acute obstetric condition * Previously diagnosed psychiatric disorder * Current use of psychiatric medication * Age younger than 18 years or older than 45 years

Design outcomes

Primary

Measure	Time frame	Description
Association Between Maternal Anxiety Level and NST Parameters	At study enrollment, during the same-day assessment	The association between Beck Anxiety Inventory scores and fetal non-stress test parameters will be evaluated.
Association Between Maternal Thyroid Function and NST Parameters	At study enrollment, using third-trimester thyroid function test results and same-day NST assessment	The association between maternal TSH and free T4 levels and fetal non-stress test parameters will be evaluated.

Secondary

Measure	Time frame
Association of Sociodemographic and Obstetric Characteristics With Maternal Anxiety, Thyroid Function, and NST Parameters	At study enrollment, using third-trimester thyroid function test results and same-day NST and anxiety assessment

Countries

Turkey (Türkiye)

Contacts

CONTACTDoruk C Katlan

dcek2000@yahoo.com+905353475411

Outcome results