Efficacy Validation of Deep Microspicule Cream for Anti-aging and Whitening on Mature Skin
Conditions
Keywords
Microspicule, Anti-aging, Whitening
Brief summary
This study is a single-center, prospective, split-face self-controlled pilot trial designed to evaluate the anti-aging and whitening efficacy of the "Deep Microspicule Cream" (containing patented crystal microspicules encapsulating Penghu seaweed extract) on mature skin.
Detailed description
This study is a single-center, prospective, split-face self-controlled pilot trial. 10 healthy participants aged 40-65 who present signs of skin aging or hyperpigmentation will be enrolled. Intervention Side (Active): Participants will apply a green-bean-sized amount of Deep Microspicule Cream on the assigned side, gently massaging to let the microspicules roll on the skin, followed by the application of Deep Essence to dissolve the microspicules. Control Side: Participants will apply Deep Essence only. The applications are performed 3 times per week at bedtime. Clinical evaluations and instrument measurements are scheduled at Day 0 (baseline), Day 14, and Day 28. On assessment days, participants must cleanse their faces and rest in a controlled environment for 25-30 minutes without applying any cosmetics before undergoing non-invasive skin assessments.
Interventions
OTHERDeep Microspicule Cream
"A topical cream (Deep Microspicule Cream) utilizing patented crystal microspicule technology to encapsulate Penghu seaweed extracts (including Caulerpa microphysa, Sargassum hemiphyllum, and Botryocladia leptopoda). These ingredients possess potential anti-inflammatory, antioxidant, and collagen-promoting properties. Participants will apply a green-bean-sized amount of the cream strictly to the randomly assigned intervention side of the face (left or right). The cream should be massaged gently on the designated side to allow the microspicules to roll on the skin surface (avoiding harsh rubbing). This application regimen is to be performed three times per week (Mondays, Wednesdays, and Saturdays) at night after facial cleansing, for a total duration of 28 days."
Sponsors
Chung Shan Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male or female participants aged 40-65 years. * Presence of at least one facial aging or hyperpigmentation feature (e.g., eye area sagging, eye bags, crow's feet, fine lines, freckles, sun spots, uneven skin tone, or dullness). * Willing to complete 3 study visits within 4 weeks, comply with instrumental measurements, and maintain product logs. * Willing to sign the Informed Consent Form (ICF).
Exclusion criteria
* Received facial aesthetic treatments (e.g., lasers, chemical peels, microneedling, energy-based therapies) within 4 weeks. * Used topical/oral retinoic acid or strong whitening creams (e.g., high-concentration hydroquinone) within 4 weeks. * Severe sensitive skin, active atopic dermatitis, or obvious facial skin lesions/infections. * Facial salon or exfoliation treatments more frequent than once every 2 weeks. * Known allergy to seaweed-derived ingredients or product preservative systems. * Uncontrolled systemic diseases (e.g., diabetes, kidney/liver/cardiovascular diseases, severe infections, endocrine disorders, or cancer). * Pregnant, lactating, or planning to become pregnant. * Deemed unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin Hydration,Transepidermal Water Loss (TEWL),Skin Elasticity,Erythema Index,Skin Color | Baseline (Day 0), Day 14, Day 28 | "Using the Cutometer® MPA 580 to sequentially measure skin hydration, transepidermal water loss (TEWL), skin elasticity, erythema index, and skin color." |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| skin texture smoothness, visual radiance (glossiness), and skin firmness | Baseline (Day 0), Day 14, Day 28 | "Subjective evaluation of skin improvement including skin feel (texture smoothness), visual radiance (glossiness), and skin firmness, assessed via a 7-point Likert scale (ranging from 1 = very dissatisfied to 7 = very satisfied) . |
Countries
Taiwan
Contacts
CONTACTYou-Cheng Mr Shen, Ph.D.
Outcome results
None listed