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Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

A Pilot Study to Assess Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07773155
Enrollment
120
Registered
2026-08-19
Start date
2025-03-17
Completion date
2027-02-01
Last updated
2026-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery, Upper Extremity

Keywords

Wrist Surgery, Hand Surgery, Pain Management

Brief summary

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.

Detailed description

Participants will be enrolled in two sequential groups: * The first group will be consented for a post-operative pain control regimen consisting of an intraoperative regional nerve block and 3 days of round-the-clock oral ketorolac, plus prescription strength acetaminophen as needed. These analgesic elements are standard of care for patients undergoing the procedures of interest, as an alternative to opioid use, though subjects of this study will be asked to use them as first-line therapy and receive other medications only for breakthrough pain. * The second group will be consented for a post-operative pain control regimen consisting of a standard care regimen of intraoperative regional nerve block and 3 days of round-the-clock opioids. Patients in both groups will be asked to complete surveys in which they rate their pain score and describe what medications they have taken for pain.

Interventions

Regional Nerve Block + Toradol + Acetaminophen

DRUGOxycodone

Regional Nerve Block + Oxycodone + Acetaminophen

Sponsors

University of Chicago
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Age 18 years or older 2. Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago. 3. Undergoing procedure with regional nerve block

Exclusion criteria

1. Age less than 18 years 2. Concomitant chronic opioid use 3. Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture 4. Medical contraindication to ketorolac use, including pregnancy 5. Undergoing multiple concurrent surgical procedures 6. Unable to communicate numerical pain score

Design outcomes

Primary

MeasureTime frameDescription
Postoperative Pain, as measured by the Numeric Pain Scale2 days, 1 week and 2 weeks post opThe numerical pain rating scale is used for rating postoperative pain. Pain scores rate from 0 to 10, with higher scores indicating more severe pain.

Secondary

MeasureTime frameDescription
Opioid requirements, measured in oral morphine equivalentsThrough 2 weeks postopOpioid requirements for breakthrough pain will be measured in Ketorolac (Toradol) group in Oral Morphine Equivalents (OME).

Countries

United States

Contacts

CONTACTJennifer Wolf, MD
jwolf@bsd.uchicago.edu773-795-3583

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 20, 2026