Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession

Assessment of Injectable Hyaluronic Acid Combined With Polynucleotides With Coronally Advanced Flap and Connective Tissue Graft in Treatment of RT II Gingival Recession Defects for Covering Gingival Recession

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07771244

Enrollment

Registered

2026-08-18

Start date

2026-09-01

Completion date

2027-03-01

Last updated

2026-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

RT II Gingival Recession

Keywords

Gingival Recession, RT II Gingival Recession, Hyaluronic Acid, Polynucleotides, Coronally Advanced Flap, Connective Tissue Graft

Brief summary

This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession. Twelve patients will be included and followed for 6 months. Clinical outcomes will include percentage of root coverage, clinical attachment level gain, gingival thickness, probing depth, width of keratinized tissue, post-operative pain, and patient aesthetic satisfaction.

Detailed description

Patients with RT II gingival recession will be treated using a coronally advanced flap combined with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing. Patients will be followed for 6 months. Clinical measurements will include recession depth and width, percentage of root coverage, clinical attachment level, gingival thickness, probing depth, keratinized tissue width, post-operative pain, and patient esthetic satisfaction.

Interventions

PROCEDURECoronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides

A coronally advanced flap will be performed with a de-epithelialized connective tissue graft. Approximately 1-2 mL of a hyaluronic acid and polynucleotide mixture will be applied to the graft before suturing

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

All participants will receive the same intervention consisting of coronally advanced flap and connective tissue graft combined with hyaluronic acid and polynucleotides.

Eligibility

Sex/Gender

ALL

Age

15 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Patients with RT II gingival recession. * Age range: 15-60 years. * Systemically healthy patients with no contraindications to surgery. * Patients who have not had previous periodontal surgery in the area of treatment.

Exclusion criteria

* Periodontitis. * Active systemic disease affecting wound healing. * Pregnancy or breastfeeding. * Improperly aligned teeth or teeth with cervical restorations or crowns. * Non-carious cervical lesions

Design outcomes

Primary

Measure	Time frame	Description
Percentage of Root Coverage	Baseline, 1 month, 3 months, and 6 months	Percentage of root coverage will be calculated using the following formula: (Initial Recession Depth - Post-Treatment Recession Depth) / Initial Recession Depth × 100.
Clinical Attachment Level (CAL) Gain	Baseline, 3 months, and 6 months	Clinical attachment level will be measured in millimetres using a UNC-15 periodontal probe

Secondary

Measure	Time frame	Description
Recession Depth	Baseline, 3 months, and 6 months	Gingival recession depth will be measured in millimeters using a UNC-15 periodontal probe
Recession Width	Baseline, 3 months, and 6 months	Gingival recession width will be measured in millimeters using a UNC-15 periodontal probe.
Gingival Thickness	Baseline, 3 months, and 6 months	Gingival thickness will be measured in millimeters using an endodontic file
Probing Depth	Baseline, 3 months, and 6 months	Probing depth will be measured in millimeters using a UNC-15 periodontal probe.
Width of Keratinized Tissue	Baseline, 3 months, and 6 months	Keratinized tissue width will be measured in millimeters using a UNC-15 periodontal probe
Post-Operative Pain	1 week post-surgery	Post-operative pain will be assessed using a Visual Analogue Scale (VAS) questionnaire, with scores ranging from 1 to 10
Patient Esthetic Satisfaction	3 months and 6 months	Patient esthetic satisfaction will be assessed using a Visual Analogue Scale (VAS) questionnaire, with scores ranging from 1 to 10

Countries

Egypt

Contacts

CONTACTHASSAN NIDAL FANDI, BDS

hassan.fandi@dentistry.cu.edu.eg+201011066726

PRINCIPAL_INVESTIGATORHASSAN NIDAL FANDI, BDS

Cairo University

STUDY_CHAIRDr.Manal Hosny