Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching

Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching on Color Change and Tooth Sensitivity: Randomized Clinical Trial

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07770373

Enrollment

Registered

2026-08-18

Start date

2026-08-01

Completion date

2026-08-01

Last updated

2026-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Discolored Teeth

Keywords

bleaching, desensitizing agents, discoloration

Brief summary

To evaluate the effect of prophylaxis pastes with and without desensitizing agents prior to in-office bleaching on color change and tooth sensitivity.

Interventions

OTHERTreatment

Prophylaxis paste will be applied to all tooth surfaces using a prophy cup attached to a low-speed contra-angle handpiece. The paste will remain on the teeth for the duration specified in the manufacturer's instructions for use before being rinsed away.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Patients who have discolored teeth, minimum of 20 natural teeth, good oral hygiene, do not have any systemic disease.

Exclusion criteria

* Patients who have extensive prosthesis or restoration, tetracycline discoloration or fluorosis, endodontically treated teeth or gingival recession, smokers, periodontal disease, pregnant or lactating.

Design outcomes

Primary

Measure	Time frame	Description
Color change	Baseline, Immediate after bleaching	Tooth color will be measured using the VITA Easyshade V spectrophotometer. Color measurements will be recorded in the CIE L\, a\, and b\* color space, and the color difference will be calculated using the CIEDE2000 color-difference formula (ΔE00).

Secondary

Measure	Time frame	Description
Tooth sensitivity	Baseline, Immediate after bleaching	Pain intensity will be assessed using a 10-cm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst pain imaginable). Patients will be asked to place a mark on the 10-cm VAS corresponding to the intensity of their pain.

Contacts

CONTACTZeinab O Tolba, Associate Professor

zeinab.omar@dentistry.cu.edu.eg+2 01222308738

CONTACTPossy M Abd El Aziz, Associate Professor

possy.moustafa@dentistry.cu.edu.eg+2 01061023968

PRINCIPAL_INVESTIGATORZeinab O Tolba, Associate Professor

Cairo University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 19, 2026