Fetal Growth Restriction (FGR)
Conditions
Keywords
Fetal Growth Restriction, Diffusion-Weighted Imaging, Fetal MRI, MCA Doppler, Cerebral Redistribution
Brief summary
This prospective observational study aims to compare fetal brain diffusion-weighted magnetic resonance imaging (DWI) findings in fetuses with and without fetal growth restriction (FGR) and to evaluate the association between middle cerebral artery (MCA) Doppler findings and regional apparent diffusion coefficient (ADC) values. Participants will be classified into three groups: fetuses with FGR and normal MCA Doppler findings, fetuses with FGR and MCA Doppler redistribution, and appropriately grown for gestational age (AGA) healthy control fetuses with normal Doppler findings. Fetal DWI will be performed using a 1.5-Tesla MRI scanner, and ADC values will be measured in predefined brain regions, including the frontal, occipital, and temporal white matter, thalamus, pons, cerebellar hemispheres, and centrum semiovale. The primary objective is to compare regional ADC values between fetuses with FGR and healthy controls. The secondary objective is to determine whether ADC values differ between FGR fetuses with normal MCA Doppler findings and those with MCA Doppler redistribution. The study also aims to evaluate the relationship between ADC values, gestational age, fetal biometric measurements, and Doppler parameters.
Interventions
DIAGNOSTIC_TESTDiffusion-weighted fetal brain MRI
Fetal diffusion-weighted magnetic resonance imaging (DWI) will be performed using a 1.5-Tesla MRI scanner. Diffusion-weighted images will be acquired with b-values of 0 and 1000 s/mm², and apparent diffusion coefficient (ADC) maps will be generated. Region-of-interest (ROI)-based ADC measurements will be obtained from predefined fetal brain regions.
Sponsors
Istanbul Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancy * Gestational age between 28 and 38 weeks * Maternal age between 18 and 45 years * For the FGR groups: estimated fetal weight (EFW) below the 10th percentile and/or abdominal circumference (AC) below the 10th percentile * For the control group: EFW and AC between the 10th and 90th percentiles, normal fetal Doppler findings, and no major structural anomaly on fetal anatomical examination * Written informed consent for participation in the study
Exclusion criteria
* Multiple pregnancy * Major fetal structural anomaly or diagnosed chromosomal abnormality * Contraindication to MRI, such as an MRI-incompatible implant * Maternal uncontrolled diabetes mellitus, significant thyroid disease, severe uncontrolled chronic hypertension, or other significant systemic chronic disease * Maternal age below 18 or above 45 years * Inability or unwillingness to provide informed consent or cooperate with study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional Fetal Brain Apparent Diffusion Coefficient (ADC) Values | At the time of fetal MRI examination (28-38 weeks of gestation) | Apparent diffusion coefficient (ADC) values will be measured using region-of-interest (ROI) analysis on fetal diffusion-weighted MRI in the frontal, occipital, and temporal white matter, thalamus, pons, cerebellar hemispheres, and centrum semiovale. Mean ADC values will be compared among fetuses with FGR and normal MCA Doppler, fetuses with FGR and MCA Doppler redistribution, and AGA healthy controls. ADC values will be expressed in mm²/s. |
Countries
Turkey (Türkiye)
Contacts
CONTACTDoruk C Katlan
Outcome results
None listed