Adenocarcinoma of the Breast, Breast Cancer, Triple Negative Breast Cancer
Conditions
Keywords
adenocarcinoma of the breast, breast cancer, triple negative breast cancer, Memorial Sloan Kettering Cancer Center, 26-303
Brief summary
The purpose of this study is to find out if it is practical (feasible) to give dose-dense CMF (cyclophosphamide, methotrexate, and fluorouracil) in two standard chemotherapy regimens in people with breast cancer, age 70 and older.
Interventions
DRUGCMF Regimen
CMF regimen: Cyclophosphamide, Methotrexate, and Fluorouracil
DRUGPaclitaxel
Paclitaxel will be administered as an IV infusion into a peripheral or central vein.
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients must have histologically confirmed adenocarcinoma of the breast confirmed at MSK. The patient must have had diagnostic biopsy or completion of primary surgical management, within 3 months of enrollment. Results of HER-2/neu, estrogen receptor, and progesterone receptor are required for study entry. * Patients must be ≥ 70 years of age. * Patients must have ECOG performance status \>2 (Karnofsky score of ≥ 60%). * Patients may have received hormonal therapy for the purpose of chemoprevention. * Adjuvant/neoadjuvant chemotherapy decision to treat based on the discretion of investigator * Cohort 1 only: Patients have any histology except Her 2 Neu positive in the adjuvant or neoadjuvant setting * Cohort 2 only: Patients have triple negative (ER- (10%) PR-Her 2 Neu -) in the neoadjuvant setting * Cohort 2 only: Patients have received at least 1 dose of carboplatin/paclitaxel +/- pembrolizumab in the neoadjuvant setting Required Organ Function Adequate hematologic function defined as follows: * Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3 * Platelets ≥ 100,000 cells/mm3 Adequate renal function defined as follows: ° Creatinine clearance (CrCL) of \>30 mL/min by the Cockcroft-Gault formula: CrCl (mL/min) = \[(\[140 - age(years)\] x weight (kg))/72 x creatinine (mg/dL)\] (x 0.85 for female patients) Adequate hepatic function defined as follows: * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled) * AST and ALT ≤3 x institutional ULN * Patients or their Legally Authorized Representative must give written, informed consent indicating their understanding and willingness to participate in the study.
Exclusion criteria
* Stage IV breast cancer * CARG score- high Frail 4 or more as assessed by CAIT * Her 2 Neu positive 3+/amplified breast cancer * No prior chemotherapy within 1 year of study enrollment * Cohort 2 only: patients may not receive pembrolizumab during dd CMF treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants who have completed all four cycles of CMF | 6 months | Evaluate the feasibility of 4 cycles of ddCMF as an alternative to AC in 2 standard regimens in patients \> or = to age 70 with breast cancer. Feasibility is evaluated by the completion of all four cycles of CMF. |
Countries
United States
Contacts
CONTACTPamela Drullinsky, MD
CONTACTKoshy Alexander, MD, MBA
PRINCIPAL_INVESTIGATORPamela Drullinsky, MD
Memorial Sloan Kettering Cancer Center
Outcome results
None listed